Journal article
Dysbindin ( DTNBP1) – A role in psychotic depression?
Journal of Psychiatric Research, Vol.45(5), pp.588-595
2011
PMID: 20951386
Abstract
Previous studies yielded evidence for dysbindin (DTNBP1) to impact the pathogenesis of schizophrenia on the one hand and affective disorders such as bipolar or major depressive disorder (MDD) on the other. Thus, in the present study we investigated whether DTNBP1 variation was associated with psychotic depression as a severe clinical manifestation of MDD possibly constituting an overlapping phenotype between affective disorders and schizophrenia.
A sample of 243 Caucasian inpatients with MDD (SCID-I) was genotyped for 12 SNPs spanning 92% of the DTNBP1 gene region. Differences in DTNBP1 genotype distributions across diagnostic subgroups of psychotic (N = 131) vs. non-psychotic depression were estimated by Pearson Chi2 test and logistic regression analyses adjusted for age, gender, Beck Depression Inventory (BDI) and the Global Assessment of Functioning Scale (GAF).
Overall, patients with psychotic depression presented with higher BDI and lower GAF scores expressing a higher severity of the illness as compared to depressed patients without psychotic features. Four DTNBP1 SNPs, particularly rs1997679 and rs9370822, and the corresponding haplotypes, respectively, were found to be significantly associated with the risk of psychotic depression in an allele-dose fashion.
In summary, the present results provide preliminary support for dysbindin (DTNBP1) gene variation, particularly SNPs rs1997679 and rs9370822, to be associated with the clinical phenotype of psychotic depression suggesting a possible neurobiological mechanism for an intermediate trait on the continuum between affective disorders and schizophrenia.
Details
- Title
- Dysbindin ( DTNBP1) – A role in psychotic depression?
- Authors
- Katharina Domschke (Author) - University of MuensterBruce Lawford (Author) - Royal Brisbane and Women's HospitalRoss Young (Author) - Queensland University of TechnologyJoanne Voisey (Author) - Queensland University of TechnologyC. Phillip Morris (Author) - Queensland University of TechnologyTilmann Roehrs (Author) - University of MuensterChrista Hohoff (Author) - University of MuensterEva Birosova (Author) - James Cook UniversityVolker Arolt (Author) - University of MuensterBernhard T Baune (Author) - James Cook University
- Publication details
- Journal of Psychiatric Research, Vol.45(5), pp.588-595
- Publisher
- Elsevier Ltd
- DOI
- 10.1016/j.jpsychires.2010.09.014
- ISSN
- 1879-1379
- PMID
- 20951386
- Organisation Unit
- Office of the Deputy Vice-Chancellor (Research and Innovation); University of the Sunshine Coast, Queensland
- Language
- English
- Record Identifier
- 99550998402621
- Output Type
- Journal article
Metrics
14 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- International collaboration
- Web Of Science research areas
- Psychiatry
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites