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Dynamic networks of psychological symptoms, impairment, substance use, and social support: The evolution of psychopathology among emerging adults
Journal article   Open access   Peer reviewed

Dynamic networks of psychological symptoms, impairment, substance use, and social support: The evolution of psychopathology among emerging adults

Jacob J Crouse, Nicholas Ho, Jan Scott, Richard Parker, Shin Ho Park, Baptiste Couvy-Duchesne, Brittany Mitchell, Enda M Byrne, Daniel F Hermens, Sarah E Medland, …
European Psychiatry, Vol.65(1), pp.1-8
2022
DOI: https://doi.org/10.1192/j.eurpsy.2022.23
PMCID: PMC9280922
PMID: 35694845
Appears in  Thompson Institute Research Collection
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Dynamic networks of psychological symptoms, impairment, substance use, and social support - The evolution of psychopathology among emerging adults VoR535.27 kBDownloadView
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Abstract

Psychopathology Youth mental health Prospective Cohort Network analysis Other Collaborations Thompson Institute Special Collection UniSC Diversity Area - Life Stages
Background: Subthreshold or attenuated syndromes are established precursors of full31 threshold mood and psychotic disorders. However less is known about the individual symptoms that may precede the development of subthreshold syndromes and associated social and functional outcomes among emerging adults who are in the peak period of onset of mental disorders. Methods: We modelled two Dynamic Bayesian networks (DBN) to investigate associations among self-rated phenomenology and personal and lifestyle factors (including role impairment, low social support, and alcohol and substance use) across the 19Up and 25Up waves of the Brisbane Longitudinal Twin Study. We examined whether symptoms and personal and lifestyle factors at 19Up were associated with (1) themselves or different items at 25Up, and (2) onset of a depression-like, hypo-manic-like, or psychotic-like subthreshold syndrome at 25Up. Results: The first DBN identified 11 items that when endorsed at 19Up were more likely to be re-endorsed at 25Up (e.g., hypersomnia, daily smoking, impaired concentration, impaired sleep quality) and seven items that when endorsed at 19Up were associated with different items being endorsed at 25Up (e.g., earlier fatigue and later role impairment; earlier anergia and later somatic pain; earlier elation and later increased self-esteem; earlier impaired concentration and later feeling stressed). In the second DBN, no arcs met our a priori threshold for inclusion. In an exploratory post-hoc model with no set threshold, >20 items at 19Up were associated with progression to a subthreshold syndrome at 25Up (albeit with low statistical confidence); the top five arcs were: feeling threatened by others and a later psychotic-like subthreshold syndrome; increased activity and a later hypo-manic-like subthreshold syndrome; and anergia, impaired sleep quality, and/or hypersomnia and a later depression-like subthreshold syndrome. Conclusions: These probabilistic models identify a set of symptoms and personal and lifestyle factors that might prove useful targets for indicated preventative strategies, pending replication.

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