Dynamic networks of psychological symptoms, impairment, substance use, and social support: The evolution of psychopathology among emerging adults

Jacob J Crouse; Nicholas Ho; Jan Scott; Richard Parker; Shin Ho Park; Baptiste Couvy-Duchesne; Brittany Mitchell; Enda M Byrne; Daniel F Hermens; Sarah E Medland; Nicholas G Martin; Nathan A Gillespie; Ian B Hickie

doi:10.1192/j.eurpsy.2022.23

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Dynamic networks of psychological symptoms, impairment, substance use, and social support: The evolution of psychopathology among emerging adults

Journal article

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Dynamic networks of psychological symptoms, impairment, substance use, and social support: The evolution of psychopathology among emerging adults

Jacob J Crouse, Nicholas Ho, Jan Scott, Richard Parker, Shin Ho Park, Baptiste Couvy-Duchesne, Brittany Mitchell, Enda M Byrne, Daniel F Hermens, Sarah E Medland, …

European Psychiatry, Vol.65(1), pp.1-8

2022

DOI: https://doi.org/10.1192/j.eurpsy.2022.23

Appears in Thompson Institute Research Collection

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Abstract

Psychopathology

Youth mental health

Prospective

Cohort

Network analysis

Other Collaborations

Thompson Institute Special Collection

UniSC Diversity Area - Life Stages

Background: Subthreshold or attenuated syndromes are established precursors of full31 threshold mood and psychotic disorders. However less is known about the individual symptoms that may precede the development of subthreshold syndromes and associated social and functional outcomes among emerging adults who are in the peak period of onset of mental disorders. Methods: We modelled two Dynamic Bayesian networks (DBN) to investigate associations among self-rated phenomenology and personal and lifestyle factors (including role impairment, low social support, and alcohol and substance use) across the 19Up and 25Up waves of the Brisbane Longitudinal Twin Study. We examined whether symptoms and personal and lifestyle factors at 19Up were associated with (1) themselves or different items at 25Up, and (2) onset of a depression-like, hypo-manic-like, or psychotic-like subthreshold syndrome at 25Up. Results: The first DBN identified 11 items that when endorsed at 19Up were more likely to be re-endorsed at 25Up (e.g., hypersomnia, daily smoking, impaired concentration, impaired sleep quality) and seven items that when endorsed at 19Up were associated with different items being endorsed at 25Up (e.g., earlier fatigue and later role impairment; earlier anergia and later somatic pain; earlier elation and later increased self-esteem; earlier impaired concentration and later feeling stressed). In the second DBN, no arcs met our a priori threshold for inclusion. In an exploratory post-hoc model with no set threshold, >20 items at 19Up were associated with progression to a subthreshold syndrome at 25Up (albeit with low statistical confidence); the top five arcs were: feeling threatened by others and a later psychotic-like subthreshold syndrome; increased activity and a later hypo-manic-like subthreshold syndrome; and anergia, impaired sleep quality, and/or hypersomnia and a later depression-like subthreshold syndrome. Conclusions: These probabilistic models identify a set of symptoms and personal and lifestyle factors that might prove useful targets for indicated preventative strategies, pending replication.

Details

Title: Dynamic networks of psychological symptoms, impairment, substance use, and social support: The evolution of psychopathology among emerging adults
Authors: Jacob J Crouse (Corresponding Author) - The University of Sydney
Nicholas Ho (Author) - The University of Sydney
Jan Scott (Author) - University of Newcastle Australia
Richard Parker (Author) - QIMR Berghofer Medical Research Institute
Shin Ho Park (Author) - The University of Sydney
Baptiste Couvy-Duchesne (Author) - The University of Queensland
Brittany Mitchell (Author) - QIMR Berghofer Medical Research Institute
Enda M Byrne (Author) - QIMR Berghofer Medical Research Institute
Daniel F Hermens (Author) - University of the Sunshine Coast, Queensland, Thompson Institute
Sarah E Medland (Author) - QIMR Berghofer Medical Research Institute
Nicholas G Martin (Author) - QIMR Berghofer Medical Research Institute
Nathan A Gillespie (Author) - Virginia Commonwealth University
Ian B Hickie (Author) - The University of Sydney
Publication details: European Psychiatry, Vol.65(1), pp.1-8
Publisher: Cambridge University Press
Date published: 2022
DOI: 10.1192/j.eurpsy.2022.23
ISSN: 1778-3585; 0924-9338
Copyright note: © The Author(s), 2022. Published by Cambridge University Press on behalf of the European Psychiatric Association. This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.
Grants: Genetics of complex traits in multiply phenotyped twin sibships: the Brisbane Longitudinal Twin Study, 1031119, National Health and Medical Research Council (Australia, Canberra) - NHMRC
Exploring modifiable candidate risk factors for mental illness in young adults: Infection, vitamin D and stress, 1049911, National Health and Medical Research Council (Australia, Canberra) - NHMRC
Clinical and neurobiological predictors of onset of major mental disorders (mania, psychosis, severe depression), and associated functional impairment, in adolescent and young adult twins: A prospective longitudinal study, 1069141, National Health and Medical Research Council (Australia, Canberra) - NHMRC
Grant note: NIH grants (K99R00, R00DA023549)
Organisation Unit: Thompson Institute
Language: English
Record Identifier: 99649778802621
Output Type: Journal article

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Web Of Science research areas: Psychiatry

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