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Dynamic modelling of chronotype and hypo manic and depressive symptoms in young people with emerging mental disorders2.88 MB
Published VersionCC BY V4.0, Open Access
Journal article
Dynamic modelling of chronotype and hypo/manic and depressive symptoms in young people with emerging mental disorders
Chronobiology International, Vol.40(6), pp.699-709
2023
PMID: 37132360
Appears in Thompson Institute Research Collection
Abstract
There is significant interest in the possible influence of chronotype on clinical states in young people with emerging mental disorders. We apply a dynamic approach (bivariate latent change score modelling) to examine the possible prospective influence of chronotype on depressive and hypo or manic symptoms in a youth cohort with predominantly depressive, bipolar, and psychotic disorders (N = 118; 14-30-years), who completed a baseline and follow-up assessment of these constructs (mean interval = 1.8-years). Our primary hypotheses were that greater baseline eveningness would predict increases in depressive but not hypo or manic symptoms. We found moderate to strong autoregressive effects for chronotype (β = -0.447 to −0.448, p < 0.001), depressive (β = -0.650, p < 0.001) and hypo or manic symptoms (β = -0.819, p < 0.001). Against our predictions, baseline chronotypes did not predict change in depressive (β = -0.016, p = 0.810) or hypo or manic symptoms (β = 0.077, p = 0.104). Similarly, the change in chronotype did not correlate with the change in depressive symptoms (β = -0.096, p = 0.295) nor did the change in chronotype and the change in hypo or manic symptoms (β = -0.166, p = 0.070). These data suggest that chronotypes may have low utility for predicting future hypo or manic and depressive symptoms in the short term, or that more frequent assessments over longer periods are needed to observe these associations. Future studies should test whether other circadian phenotypes (e.g. sleep-wake variability) are better indicators of illness course.
Details
- Title
- Dynamic modelling of chronotype and hypo/manic and depressive symptoms in young people with emerging mental disorders
- Authors
- Timothy R. Wong (Author) - The University of SydneyIan B. Hickie (Author) - The University of SydneyJoanne S. Carpenter (Author) - The University of SydneyElizabeth M. Scott (Author) - The University of SydneyAdam J. Guastella (Author) - The University of SydneyParisa Vidafar (Author) - The University of SydneyJan Scott (Author) - The University of SydneyDaniel F. Hermens (Author) - University of the Sunshine Coast, Queensland, Thompson InstituteJacob J. Crouse (Corresponding Author) - The University of Sydney
- Publication details
- Chronobiology International, Vol.40(6), pp.699-709
- Publisher
- Taylor & Francis
- Date published
- 2023
- DOI
- 10.1080/07420528.2023.2203241
- ISSN
- 1525-6073; 0742-0528
- PMID
- 37132360
- Copyright note
- © 2023 The Author(s). Published with license by Taylor & Francis Group, LLC. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc- nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.
- Grants
- Organisation Unit
- Thompson Institute
- Language
- English
- Record Identifier
- 99723798902621
- Output Type
- Journal article
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