Dynamic modelling of chronotype and hypo/manic and depressive symptoms in young people with emerging mental disorders

Timothy R. Wong; Ian B. Hickie; Joanne S. Carpenter; Elizabeth M. Scott; Adam J. Guastella; Parisa Vidafar; Jan Scott; Daniel F. Hermens; Jacob J. Crouse

doi:10.1080/07420528.2023.2203241

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Dynamic modelling of chronotype and hypo/manic and depressive symptoms in young people with emerging mental disorders

Journal article

Open access

Peer reviewed

Dynamic modelling of chronotype and hypo/manic and depressive symptoms in young people with emerging mental disorders

Timothy R. Wong, Ian B. Hickie, Joanne S. Carpenter, Elizabeth M. Scott, Adam J. Guastella, Parisa Vidafar, Jan Scott, Daniel F. Hermens and Jacob J. Crouse

Chronobiology International, Vol.40(6), pp.699-709

2023

DOI: https://doi.org/10.1080/07420528.2023.2203241

PMID: 37132360

Appears in Thompson Institute Research Collection

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Abstract

bipolar

circadian preference

depression

Diurnal preference

mania

mood disorders

psychopathology

psychosis

Other Collaborations

Thompson Institute Special Collection

UniSC Diversity Area - Disability and Inclusion

There is significant interest in the possible influence of chronotype on clinical states in young people with emerging mental disorders. We apply a dynamic approach (bivariate latent change score modelling) to examine the possible prospective influence of chronotype on depressive and hypo or manic symptoms in a youth cohort with predominantly depressive, bipolar, and psychotic disorders (N = 118; 14-30-years), who completed a baseline and follow-up assessment of these constructs (mean interval = 1.8-years). Our primary hypotheses were that greater baseline eveningness would predict increases in depressive but not hypo or manic symptoms. We found moderate to strong autoregressive effects for chronotype (β = -0.447 to −0.448, p < 0.001), depressive (β = -0.650, p < 0.001) and hypo or manic symptoms (β = -0.819, p < 0.001). Against our predictions, baseline chronotypes did not predict change in depressive (β = -0.016, p = 0.810) or hypo or manic symptoms (β = 0.077, p = 0.104). Similarly, the change in chronotype did not correlate with the change in depressive symptoms (β = -0.096, p = 0.295) nor did the change in chronotype and the change in hypo or manic symptoms (β = -0.166, p = 0.070). These data suggest that chronotypes may have low utility for predicting future hypo or manic and depressive symptoms in the short term, or that more frequent assessments over longer periods are needed to observe these associations. Future studies should test whether other circadian phenotypes (e.g. sleep-wake variability) are better indicators of illness course.

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Title: Dynamic modelling of chronotype and hypo/manic and depressive symptoms in young people with emerging mental disorders
Authors: Timothy R. Wong (Author) - The University of Sydney
Ian B. Hickie (Author) - The University of Sydney
Joanne S. Carpenter (Author) - The University of Sydney
Elizabeth M. Scott (Author) - The University of Sydney
Adam J. Guastella (Author) - The University of Sydney
Parisa Vidafar (Author) - The University of Sydney
Jan Scott (Author) - The University of Sydney
Daniel F. Hermens (Author) - University of the Sunshine Coast, Queensland, Thompson Institute
Jacob J. Crouse (Corresponding Author) - The University of Sydney
Publication details: Chronobiology International, Vol.40(6), pp.699-709
Publisher: Taylor & Francis
Date published: 2023
DOI: 10.1080/07420528.2023.2203241
ISSN: 1525-6073
PMID: 37132360
Copyright note: © 2023 The Author(s). Published with license by Taylor & Francis Group, LLC. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc- nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.
Grants: Optimising early interventions for young people with emerging mood disorder, 1061043, National Health and Medical Research Council (Australia, Canberra) - NHMRC
Investigating body clock dysfunction in mood disorders using wearable sensors, 2008197, National Health and Medical Research Council (Australia, Canberra) - NHMRC
Organisation Unit: Thompson Institute
Language: English
Record Identifier: 99723798902621
Output Type: Journal article

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