Duration of cannabis use — a novel phenotype?

M T Lynskey; J D Grant; E C Nelson; K K Bucholz; P A F Madden; Dixie J Statham; N G Martin; A C Heath

doi:10.1016/j.addbeh.2006.03.048

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Duration of cannabis use — a novel phenotype?

Journal article

Peer reviewed

Duration of cannabis use — a novel phenotype?

M T Lynskey, J D Grant, E C Nelson, K K Bucholz, P A F Madden, Dixie J Statham, N G Martin and A C Heath

Addictive Behaviors, Vol.31(6), pp.984-994

2006

DOI: https://doi.org/10.1016/j.addbeh.2006.03.048

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Abstract

Psychology

cannabis use

cannabis dependence

duration

twins

Although cannabis is the most commonly used illicit drug, duration of cannabis use is typically short, with manyof those who initiate cannabis use ceasing use by their late twenties. In this paper we analyze data from a volunteerAustralian cohort of 6265 male and female twins to examine whether the duration of cannabis use is an informativephenotype for future genetic analyses. Genetic modeling indicated: (a) moderate genetic influences on duration ofcannabis use in both males (41%; 95% CI=31-51) and females (55%; 95% CI=46-63); (b) strong genetic influenceson cannabis dependence in both males (72%, 95% CI=61-81) and females (62%, 95% CI=48-74); (c) no evidenceof shared environmental influences on duration of cannabis use or on cannabis dependence in either males or females.Importantly, this model fitting indicated that a substantial component of genetic influences (rg=.90, 95% CI=.77-.99(males); .70, 95% CI=.57-.83 (females)) on duration of cannabis use was shared with those influencing liability tocannabis dependence. While there were high genetic correlations in both women and men, lifetime duration ofcannabis may be uniquely informative in assessing components of liability to cannabis use.

Details

Title: Duration of cannabis use — a novel phenotype?
Authors: M T Lynskey (Author) - Washington University, United States
J D Grant (Author) - Washington University, United States
E C Nelson (Author) - Washington University, United States
K K Bucholz (Author) - Washington University, United States
P A F Madden (Author) - Washington University
Dixie J Statham (Author) - Washington University, United States
N G Martin (Author) - Washington University, United States
A C Heath (Author) - Washington University, United States
Publication details: Addictive Behaviors, Vol.31(6), pp.984-994
Publisher: Pergamon
Date published: 2006
DOI: 10.1016/j.addbeh.2006.03.048
ISSN: 0306-4603
Organisation Unit: School of Social Sciences - Legacy; University of the Sunshine Coast, Queensland
Language: English
Record Identifier: 99449718902621
Output Type: Journal article

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