Drop-out, adherence, and compliance in randomized controlled trials of exercise training in multiple sclerosis: Short report

Robert W Motl; Daniel I Russell; Lara A Pilutti; Alexandra P Metse; Claudia H Marck; Bryan Chan; Peixuan Zheng; Yvonne C Learmonth

doi:10.1177/13524585241229332

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Drop-out, adherence, and compliance in randomized controlled trials of exercise training in multiple sclerosis: Short report

Journal article

Peer reviewed

Drop-out, adherence, and compliance in randomized controlled trials of exercise training in multiple sclerosis: Short report

Robert W Motl, Daniel I Russell, Lara A Pilutti, Alexandra P Metse, Claudia H Marck, Bryan Chan, Peixuan Zheng and Yvonne C Learmonth

Multiple Sclerosis Journal, Vol.30(4-5), pp.605-611

2024

DOI: https://doi.org/10.1177/13524585241229332

PMID: 38333909

Abstract

rehabilitation

Exercise

adherence

compliance

safety

We documented reporting and rates of drop-out, adherence, and compliance from 40 randomized controlled trials (RCTs) included in our meta-analysis on safety of exercise training (ET) in MS. We adopted definitions and metrics of adherence and compliance provided by the MoXFo adherence group. Drop-out was reported in 100% of the RCTs and approximated 10% for intervention and control conditions. Adherence and compliance were reported in approximately 50% and 10% of the RCTs, respectively, and approximated 80% and 70%, respectively. Standardized metrics for reporting adherence and compliance are important in future RCTs for understanding the impact on outcomes and translation of research evidence into practice.

Details

Title: Drop-out, adherence, and compliance in randomized controlled trials of exercise training in multiple sclerosis: Short report
Authors: Robert W Motl (Corresponding Author) - University of Illinois Chicago
Daniel I Russell (Author) - Murdoch University
Lara A Pilutti (Author) - University of Ottawa
Alexandra P Metse (Author) - University of the Sunshine Coast, Queensland, School of Health - Psychology
Claudia H Marck (Author) - University of Melbourne
Bryan Chan (Author) - Murdoch University
Peixuan Zheng (Author) - University of Illinois Chicago
Yvonne C Learmonth (Author) - Murdoch University
Publication details: Multiple Sclerosis Journal, Vol.30(4-5), pp.605-611
Publisher: Sage Publications Ltd.
Date published: 2024
DOI: 10.1177/13524585241229332
ISSN: 1477-0970
PMID: 38333909
Data Availability: Data sharing is not applicable to this article as no data sets were generated or analyzed during this study.
Organisation Unit: School of Health - Psychology; Healthy Ageing Research Cluster
Language: English
Record Identifier: 991001298602621
Output Type: Journal article