Journal article
Dopamine D3 receptor gene variation: impact on electroconvulsive therapy response and ventral striatum responsiveness in depression
International Journal of Neuropsychopharmacology, Vol.16(7), pp.1443-1459
2013
PMID: 22093107
Abstract
Dysfunction of dopamine D3 receptors, particularly in the mesocorticolimbic system, has been linked to the pathogenesis of major depression. Preclinical data show enhanced D3 receptor binding in the striatum upon antidepressant medication and electroconvulsive therapy (ECT). Thus, the potential impact of dopamine D3 receptor gene (DRD3) variation on ECT outcome in treatment-resistant major depression was evaluated by applying a combined molecular and imaging genetic approach. Altogether, 10 representative variants covering 95.4% of DRD3 gene variation were investigated for association with response to ECT in a sample of 104 (71 female, 33 male) Caucasian patients with pharmacorefractory major depression. Additionally, ventral striatum responsiveness to happy faces was assessed in two independent samples of depressed patients (total N=54) by means of functional magnetic resonance imaging at 3 T. Significant association of DRD3 rs3732790, rs3773679 and rs9817063 variants with response (uncorrected p=0.02–0.03) and remission (uncorrected p=0.01) after ECT was discerned. Logistic regression analyses revealed association of rs3732790 (uncorrected p=0.009; corrected p=0.045) and rs3773679 (uncorrected p=0.009; corrected p=0.045) with remission when applying a recessive model of inheritance. The rs3732790T allele conferring a more favourable treatment response was furthermore found to be associated with stronger striatal responsiveness to happy facial expressions (sample 1: cluster-corrected p=0.002; sample 2: p=0.023). In summary, the present study suggests some impact of DRD3 gene variation on ECT response, potentially mediated by alteration of striatal engagement during the processing of emotionally rewarding stimuli.
Details
- Title
- Dopamine D3 receptor gene variation: impact on electroconvulsive therapy response and ventral striatum responsiveness in depression
- Authors
- Udo Dannlowski (Author) - University of MünsterKatharina Domschke (Author) - University of MünsterEva Birosova (Author) - James Cook UniversityBruce Lawford (Author) - Royal Brisbane and Women's Hospital FoundationRoss Young (Author) - Queensland University of TechnologyJoanne Voisey (Author) - Queensland University of TechnologyC. Phillip Morris (Author) - Queensland University of TechnologyThomas Suslow (Author) - Leipzig UniversityCarsten Konrad (Author) - Philipps University of MarburgHarald Kugel (Author) - University of MünsterPatricia Ohrmann (Author) - University of MünsterJochen Bauer (Author) - University of MünsterSonja Schöning (Author) - University of MünsterMaxim Zavorotnyy (Author) - University of MünsterJulia Diemer (Author) - University of MünsterVolker Arolt (Author) - University of MünsterBernhard T Baune (Author) - University of AdelaidePeter Zwanzger (Author) - University of Münster
- Publication details
- International Journal of Neuropsychopharmacology, Vol.16(7), pp.1443-1459; 17
- Publisher
- Oxford University Press
- DOI
- 10.1017/S1461145711001659
- ISSN
- 1469-5111
- PMID
- 22093107
- Organisation Unit
- University of the Sunshine Coast, Queensland; Office of the Deputy Vice-Chancellor (Research and Innovation)
- Language
- English
- Record Identifier
- 99550999602621
- Output Type
- Journal article
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- Domestic collaboration
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- Web Of Science research areas
- Clinical Neurology
- Neurosciences
- Pharmacology & Pharmacy
- Psychiatry
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