Journal article
Dominance of multidrug resistant CC271 clones in macrolide-resistant streptococcus pneumoniae in Arizona
BMC Microbiology, Vol.12, 12
2012
Abstract
Background: Rates of resistance to macrolide antibiotics in Streptococcus pneumoniae are rising around the world due to the spread of mobile genetic elements harboring mef(E) and erm(B) genes and post-vaccine clonal expansion of strains that carry them. Results: Characterization of 592 clinical isolates collected in Arizona over a 10 year period shows 23.6% are macrolide resistant. The largest portion of the macrolide-resistant population, 52%, is dual mef(E)/erm(B)-positive. All dual-positive isolates are multidrug-resistant clonal lineages of Taiwan 19F-14, mostly multilocus sequence type 320, carrying the recently described transposon Tn2010. The remainder of the macrolide resistant S. pneumoniae collection includes 31% mef(E)-positive, and 9% erm(B)-positive strains. Conclusions: The dual-positive, multidrug-resistant S. pneumoniae clones have likely expanded by switching to non-vaccine serotypes after the heptavalent pneumococcal conjugate vaccine release, and their success limits therapy options. This upsurge could have a considerable clinical impact in Arizona. © 2012 Bowers et al; BioMed Central Ltd.
Details
- Title
- Dominance of multidrug resistant CC271 clones in macrolide-resistant streptococcus pneumoniae in Arizona
- Authors
- J R Bowers (Author) - Translational Genomics Research Institute, United StatesE M Driebe (Author) - Translational Genomics Research Institute, United StatesJ L Nibecker (Author) - Translational Genomics Research Institute, United StatesB R Wojack (Author) - Laboratory Sciences of Arizona, United StatesDerek S Sarovich (Author) - Northern Arizona University, United StatesA H Wong (Author) - Life Technologies, United StatesP M Brzoska (Author) - Life Technologies, United StatesN Hubert (Author) - Translational Genomics Research Institute, United StatesA Knadler (Author) - Translational Genomics Research Institute, United StatesL M Watson (Author) - Northern Arizona University, United StatesD M Wagner (Author) - Northern Arizona University, United StatesM R Furtado (Author) - Life Technologies, United StatesM Saubolle (Author) - Translational Genomics Research Institute, United StatesD M Engelthaler (Author) - Translational Genomics Research Institute, United StatesP S Keim (Author) - Laboratory Sciences of Arizona, United States
- Publication details
- BMC Microbiology, Vol.12, 12; 10
- Publisher
- BioMed Central Ltd.
- Date published
- 2012
- DOI
- 10.1186/1471-2180-12-12
- ISSN
- 1471-2180
- Copyright note
- Copyright © 2012 Bowers et al; BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- Organisation Unit
- University of the Sunshine Coast, Queensland; Centre for Bioinnovation
- Language
- English
- Record Identifier
- 99450340902621
- Output Type
- Journal article
Metrics
20 File views/ downloads
238 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Industry collaboration
- Domestic collaboration
- Web Of Science research areas
- Microbiology
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites