Does Parenteral Nutrition Increase the Risk of Catheter-Related Bloodstream Infection? A Systematic Literature Review

Nicole Clare Gavin; Elise Button; Samantha Keogh; David J McMillan; Claire Rickard

doi:10.1177/0148607117714218

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Does Parenteral Nutrition Increase the Risk of Catheter-Related Bloodstream Infection? A Systematic Literature Review

Journal article

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Does Parenteral Nutrition Increase the Risk of Catheter-Related Bloodstream Infection? A Systematic Literature Review

Nicole Clare Gavin, Elise Button, Samantha Keogh, David J McMillan and Claire Rickard

Journal of Parenteral and Enteral Nutrition, Vol.41(6), pp.918-928

2017

DOI: https://doi.org/10.1177/0148607117714218

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Abstract

parenteral nutrition

central venous access device

central venous catheterization

catheter-related bloodstream infection

systematic review

Background: Central venous access devices (CVADs) are used for parenteral nutrition (PN) delivery. We systematically reviewed research-based publications that reported comparative rates of catheter-related bloodstream infection (CRBSI) in patients with CVADs who received PN vs those who did not receive PN therapy. Materials and Methods: The literature search included the Cochrane Library, MEDLINE, CINAHL, and PubMed up to July 14, 2015, to identity studies that compared patients with a CVAD who did and did not have PN therapy. Results: Eleven observational studies were identified, comprising 2854 participants with 6287 CVADs. Six studies produced significant results in favor of non-PN, 4 studies showed no evidence of a difference between PN and non-PN, and 1 study produced significant results in favor of PN when analyzed per patient with multiple CVADs. Incidence ranged from 0 to 6.6 CRBSIs per 1000 CVAD days in the PN patients and 0.39 to 3.6 CRBSIs per 1000 CVAD days in the non-PN patients. The Cochrane risk of bias assessment tool for nonrandomized studies of interventions was used. Eight studies were rated as moderate risk of bias, 2 as serious, and 1 as critical. Conclusion: The data presented in this systematic review are not sufficient to establish whether patients receiving PN are more at risk of developing CRBSI than those who do not. Future PN studies needs to adjust for baseline imbalances and improve quality and reporting.

Details

Title: Does Parenteral Nutrition Increase the Risk of Catheter-Related Bloodstream Infection? A Systematic Literature Review
Authors: Nicole Clare Gavin (Author) - Griffith University
Elise Button (Author) - Queensland University of Technology
Samantha Keogh (Author) - Griffith University
David J McMillan (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
Claire Rickard (Author) - Griffith University
Publication details: Journal of Parenteral and Enteral Nutrition, Vol.41(6), pp.918-928
Publisher: Sage Publications Inc.
Date published: 2017
DOI: 10.1177/0148607117714218
ISSN: 0148-6071
Organisation Unit: University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; School of Science, Technology and Engineering; Centre for Bioinnovation
Language: English
Record Identifier: 99450919202621
Output Type: Journal article

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Collaboration types: Domestic collaboration
Web Of Science research areas: Nutrition & Dietetics

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