Do vicinal disulfide bridges mediate functionally important redox transformations in proteins?

A D De Araujo; Volker Herzig; M J Windley; S Dziemborowicz; M Mobli; G M Nicholson; P F Alewood; G F King

doi:10.1089/ars.2013.5365

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Do vicinal disulfide bridges mediate functionally important redox transformations in proteins?

Journal article

Peer reviewed

Do vicinal disulfide bridges mediate functionally important redox transformations in proteins?

A D De Araujo, Volker Herzig, M J Windley, S Dziemborowicz, M Mobli, G M Nicholson, P F Alewood and G F King

Antioxidants and Redox Signaling, Vol.19(16), pp.1976-1980

2013

DOI: https://doi.org/10.1089/ars.2013.5365

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Abstract

Vicinal disulfide bridges, in which a disulfide bond is formed between adjacent cysteine residues, constitute an unusual but expanding class of potential allosteric disulfides. Although vicinal disulfide rings (VDRs) are relatively uncommon, they have proven to be functionally critical in almost all proteins in which they have been discovered. However, it has proved difficult to test whether these sterically constrained disulfides participate in functionally important redox transformations. We demonstrate that chemical replacement of VDRs with dicarba or diselenide bridges can be used to assess whether VDRs function as allosteric disulfides. Our approach leads to the hypothesis that not all VDRs participate in functionally important redox reactions. Antioxid. Redox Signal. 19, 1976-1980.

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Title: Do vicinal disulfide bridges mediate functionally important redox transformations in proteins?
Authors: A D De Araujo (Author) - University of Queensland
Volker Herzig (Author) - University of Queensland
M J Windley (Author) - University of Technology, Sydney
S Dziemborowicz (Author) - University of Technology, Sydney
M Mobli (Author) - University of Queensland
G M Nicholson (Author) - University of Technology, Sydney
P F Alewood (Author) - University of Queensland
G F King (Author) - University of Queensland
Publication details: Antioxidants and Redox Signaling, Vol.19(16), pp.1976-1980
Publisher: Mary Ann Liebert, Inc. Publishers
Date published: 2013
DOI: 10.1089/ars.2013.5365
ISSN: 1523-0864
Organisation Unit: School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; School of Science, Technology and Engineering; Centre for Bioinnovation
Language: English
Record Identifier: 99451333302621
Output Type: Journal article

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