Journal article
Diurnal changes of glycogen molecular structure in healthy and diabetic mice
Carbohydrate Polymers, Vol.185, pp.145-152
2018
PMID: 29421051
Abstract
Glycogen is a complex branched glucose polymer functioning as a blood-sugar reservoir in animals. Liver glycogen beta particles can bind together to form a particles, which have a slower enzymatic degradation to glucose. The linkage between beta particles in a particles in diabetic liver breaks (is fragile) in dimethyl sulfoxide (DMSO), a H-bond disruptor, consistent with blood-sugar homeostasis loss in diabetes. We examined diurnal changes in the molecular structure of healthy and diabetic mouse-liver glycogen. Healthy mouse glycogen was fragile to DMSO during glycogen synthesis but not degradation; diabetic glycogen was always fragile. Two alternative mechanisms for this are suggested: healthy glycogen is fragile when formed and becomes stable during subsequent degradation, a process damaged in diabetes; alternatively, there are two types of glycogen: one compact but fragile and the other loose but non-fragile. This suggests potential types of diabetes drug targets through modifying the activities of glycogen synthesis enzymes.
Details
- Title
- Diurnal changes of glycogen molecular structure in healthy and diabetic mice
- Authors
- Zhenxia Hu (Author) - Wuhan UniversityBin Deng (Corresponding Author) - Huazhong University of Science and TechnologyXinle Tan - University of QueenslandHua Gan - Huazhong University of Science and TechnologyCheng Li - Yangzhou UniversitySharif S. Nada - University of QueenslandMitchell A Sullivan - University of QueenslandJialun Li - Huazhong University of Science and TechnologyXiaoyin Jiang - Huazhong University of Science and TechnologyEnpeng Li - Yangzhou UniversityRobert G. Gilbert - University of Queensland
- Publication details
- Carbohydrate Polymers, Vol.185, pp.145-152
- Publisher
- Elsevier Ltd.
- Date published
- 2018
- DOI
- 10.1016/j.carbpol.2018.01.003
- ISSN
- 1879-1344
- PMID
- 29421051
- Organisation Unit
- School of Health - Biomedicine
- Language
- English
- Record Identifier
- 991035096602621
- Output Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web Of Science research areas
- Chemistry, Applied
- Chemistry, Organic
- Polymer Science
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Source: InCites