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Diurnal changes in choroidal optical coherence tomography angiography indices over 24 hours in healthy young adults2.98 MB
Published VersionCC BY V4.0, Open Access
Journal article
Diurnal changes in choroidal optical coherence tomography angiography indices over 24 hours in healthy young adults
Scientific Reports, Vol.13, pp.1-13
2023
PMID: 36864086
Abstract
This prospective study investigated the magnitude and pattern of variation in choroidal optical coherence tomography angiography (OCT-A) indices every 4 h over 24 h in healthy young myopic (n = 24) and non-myopic (n = 20) adults. Choriocapillaris and deep choroid en-face images from macular OCT-A scans were analysed from each session to extract magnification-corrected vascular indices including choriocapillaris flow deficit number, size and density and deep choroid perfusion density in the sub-foveal, sub-parafoveal, and sub-perifoveal regions. Choroidal thickness was also obtained from structural OCT scans. Significant variations over 24 h (P < 0.05) were observed in most of the choroidal OCT-A indices excluding sub-perifoveal flow deficit number, with peaks observed between 2 to 6 AM. For myopes, peaks occurred significantly earlier (3-5 h), and the diurnal amplitude was significantly greater for sub-foveal flow deficit density (P = 0.02) and deep choroidal perfusion density (P = 0.03) compared with non-myopes. Choroidal thickness also showed significant diurnal changes (P < 0.05) with peaks between 2 to 4 AM. Significant correlations were found between diurnal amplitudes or acrophases of choroidal OCT-A indices and choroidal thickness, intraocular pressure, and systemic blood pressure. This provides the first comprehensive diurnal assessment of choroidal OCT-A indices over 24 h.
Details
- Title
- Diurnal changes in choroidal optical coherence tomography angiography indices over 24 hours in healthy young adults
- Authors
- Barsha Lal (Corresponding Author) - Queensland University of TechnologyDavid Alonso-Caneiro (Author) - Queensland University of TechnologyScott A Read (Author) - Queensland University of TechnologyAndrew Carkeet (Author) - Queensland University of Technology
- Publication details
- Scientific Reports, Vol.13, pp.1-13
- Publisher
- Nature Publishing Group
- Date published
- 2023
- DOI
- 10.1038/s41598-023-30433-1
- ISSN
- 2045-2322
- PMID
- 36864086
- Copyright note
- © The Author(s) 2023. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http:// creativecommons.org/ licenses/ by/4. 0/.
- Data Availability
- The datasets generated and analysed during this study are available from the corresponding author on reasonable request.
- Organisation Unit
- School of Science, Technology and Engineering
- Language
- English
- Record Identifier
- 99973595002621
- Output Type
- Journal article
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- Ophthalmology
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