Distinguishing Health Benefits of Eicosapentaenoic and Docosahexaenoic Acids

Fraser D Russell; Corinna S Burgin-Maunder

doi:10.3390/md10112535

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Distinguishing Health Benefits of Eicosapentaenoic and Docosahexaenoic Acids

Journal article

Open access

Peer reviewed

Distinguishing Health Benefits of Eicosapentaenoic and Docosahexaenoic Acids

Fraser D Russell and Corinna S Burgin-Maunder

Marine Drugs, Vol.10(11), pp.2535-2559

2012

DOI: https://doi.org/10.3390/md10112535

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Abstract

LC n-3 PUFAs

omega-3 fatty acids

eicosapentaenoic acid

docosahexaenoic acid

resolvin D1

differential response

omega-3 fatty acid metabolites

Long chain omega-3 polyunsaturated fatty acids (LC n-3 PUFAs) are recommended for management of patients with wide-ranging chronic diseases, including coronary heart disease, rheumatoid arthritis, dementia, and depression. Increased consumption of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) is recommended by many health authorities to prevent (up to 0.5 g/day) or treat chronic disease (1.0 g/day for coronary heart disease; 1.2-4 g/day for elevated triglyceride levels). Recommendations for dietary intake of LC n-3 PUFAs are often provided for α-linolenic acid, and for the combination of EPA and DHA. However, many studies have also reported differential effects of EPA, DHA and their metabolites in the clinic and at the laboratory bench. The aim of this article is to review studies that have identified divergent responses to EPA and DHA, and to explore reasons for these differences. In particular, we review potential contributing factors such as differential membrane incorporation, modulation of gene expression, activation of signaling pathways and metabolite formation. We suggest that there may be future opportunity to refine recommendations for intake of individual LC n-3 PUFAs.

Details

Title: Distinguishing Health Benefits of Eicosapentaenoic and Docosahexaenoic Acids
Authors: Fraser D Russell (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
Corinna S Burgin-Maunder (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
Publication details: Marine Drugs, Vol.10(11), pp.2535-2559
Publisher: MDPI AG
Date published: 2012
DOI: 10.3390/md10112535
ISSN: 1660-3397
Copyright note: Copyright © 2012 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). Reproduced in accordance with this policy.
Organisation Unit: School of Health - Biomedicine; University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; Centre for Bioinnovation; School of Health and Behavioural Sciences - Legacy
Language: English
Record Identifier: 99450127402621
Output Type: Journal article

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