Distinct neurometabolic profiles are evident in the anterior cingulate of young people with major psychiatric disorders

Daniel F Hermens; Jim Lagopoulos; S L Naismith; J Tobias-Webb; I B Hickie

doi:10.1038/tp.2012.35

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Distinct neurometabolic profiles are evident in the anterior cingulate of young people with major psychiatric disorders

Journal article

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Distinct neurometabolic profiles are evident in the anterior cingulate of young people with major psychiatric disorders

Daniel F Hermens, Jim Lagopoulos, S L Naismith, J Tobias-Webb and I B Hickie

Translational Psychiatry, Vol.2, e110

2012

DOI: https://doi.org/10.1038/tp.2012.35

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Abstract

anterior cingulate

glutamate

glutathione

psychiatric

spectroscopy

youth

Currently, there are no validated neurobiological methods for distinguishing different pathophysiological pathways in young patients presenting in the early phases of major psychiatric disorders. Hence, treatments are delivered simply on the basis of their possible effects on nonspecific symptom constructs such as depression, cognitive change or psychotic symptoms. In this study, the ratios (relative to creatine) of key metabolites (N-acetyl aspartate, myoinositol, glutamate and glutathione) were measured with proton magnetic resonance spectroscopy ( 1 H-MRS) within the anterior cingulate cortex of 88 young persons presenting with major mood or psychotic symptoms. We derived empirically (using a cluster analytical technique) three subgroups of subjects on the basis of their patterns of in vivo brain biochemistry. The three subgroups were distinguished (from each other) by all the four metabolites, in particular, glutathione and glutamate. By contrast, the groups could not be distinguished by differences in terms of other demographic, functional or clinical measures. We propose that this 1 H-MRS-based subclassification system could be used as the basis for much more specific tests of novel intervention strategies (notably, antioxidant and glutamatergic therapies) early in the course of major psychiatric disorders. © 2012 Macmillan Publishers Limited All rights reserved.

Details

Title: Distinct neurometabolic profiles are evident in the anterior cingulate of young people with major psychiatric disorders
Authors: Daniel F Hermens (Author) - University of Sydney
Jim Lagopoulos (Author) - University of Sydney
S L Naismith (Author) - University of Sydney
J Tobias-Webb (Author) - University of Sydney
I B Hickie (Author) - University of Sydney
Publication details: Translational Psychiatry, Vol.2, e110
Publisher: Nature Publishing Group
Date published: 2012
DOI: 10.1038/tp.2012.35
ISSN: 2158-3188
Copyright note: Copyright © 2012 The Author. Translational Psychiatry is an open-access journal published by Nature Publishing Group. This work is licensed under the Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/
Organisation Unit: University of the Sunshine Coast, Queensland; Thompson Institute
Language: English
Record Identifier: 99449587302621
Output Type: Journal article

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