Journal article
Distinct Campylobacter fetus lineages adapted as livestock pathogens and human pathobionts in the intestinal microbiota
Nature Communications, Vol.8(1), 1367
2017
Abstract
Campylobacter fetus is a venereal pathogen of cattle and sheep, and an opportunistic human pathogen. It is often assumed that C. fetus infection occurs in humans as a zoonosis through food chain transmission. Here we show that mammalian C. fetus consists of distinct evolutionary lineages, primarily associated with either human or bovine hosts. We use whole-genome phylogenetics on 182 strains from 17 countries to provide evidence that C. fetus may have originated in humans around 10,500 years ago and may have "jumped" into cattle during the livestock domestication period. We detect C. fetus genomes in 8% of healthy human fecal metagenomes, where the human-associated lineages are the dominant type (78%). Thus, our work suggests that C. fetus is an unappreciated human intestinal pathobiont likely spread by human to human transmission. This genome-based evolutionary framework will facilitate C. fetus epidemiology research and the development of improved molecular diagnostics and prevention schemes for this neglected pathogen.
Details
- Title
- Distinct Campylobacter fetus lineages adapted as livestock pathogens and human pathobionts in the intestinal microbiota
- Authors
- G Iraola (Author)S C Forster (Author)N Kumar (Author)P Lehours (Author)S Bekal (Author)F J Garcia-Pena (Author)F Paolicchi (Author)C Morsella (Author)H Hotzel (Author)P R Hsueh (Author)A Vidal (Author)S Leversque (Author)W Yamazaki (Author)C Balzan (Author)A Vargas (Author)A Piccirillo (Author)Bonnie L Chaban (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and EngineeringJ E Hill (Author)L Betancor (Author)L Collado (Author)I Truyers (Author)A C Midwinter (Author)H T Dagi (Author)F Megraud (Author)L Calleros (Author)R Perez (Author)H Naya (Author)T D Lawley (Author)
- Publication details
- Nature Communications, Vol.8(1), 1367; 8
- Publisher
- Nature Publishing Group
- Date published
- 2017
- DOI
- 10.1038/s41467-017-01449-9
- ISSN
- 2041-1723
- Copyright note
- Copyright © The Author(s) 2017. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
- Organisation Unit
- University of the Sunshine Coast, Queensland; Thompson Institute; Centre for Bioinnovation
- Language
- English
- Record Identifier
- 99451294902621
- Output Type
- Journal article
Metrics
17 File views/ downloads
728 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- International collaboration
- Web Of Science research areas
- Microbiology
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites