Distance-dependent patterns of molecular divergences in tuatara mitogenomes

Sankar Subramanian; E Mohandesan; C D Millar; D M Lambert

doi:10.1038/srep08703

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Distance-dependent patterns of molecular divergences in tuatara mitogenomes

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Distance-dependent patterns of molecular divergences in tuatara mitogenomes

Sankar Subramanian, E Mohandesan, C D Millar and D M Lambert

Scientific Reports, Vol.5(8703)

2015

DOI: https://doi.org/10.1038/srep08703

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Abstract

Population genetic models predict that populations that are geographically close to each other are expected to be genetically more similar to each other compared to those that are widely separate. However the patterns of relationships between geographic distance and molecular divergences at neutral and constrained regions of the genome are unclear. We attempted to clarify this relationship by sequencing complete mitochondrial genomes of the relic species Tuatara (Sphenodon punctatus) from ten offshore islands of New Zealand. We observed a positive relationship that showed a proportional increase in the neutral diversity at synonymous sites (dS), with increasing geographical distance. In contrast we showed that diversity at evolutionarily constrained sites (dC) was elevated in the case of comparisons involving closely located populations. Conversely diversity was reduced in the case of comparisons between distantly located populations. These patterns were confirmed by a significant negative relationship between the ratio of dC/dS and geographic distance. The observed high dC/dS could be explained by the abundance of deleterious mutations in comparisons involving closely located populations, due to the recent population divergence times. Since distantly related populations were separated over long periods of time, deleterious mutations might have been removed by purifying selection.

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Title: Distance-dependent patterns of molecular divergences in tuatara mitogenomes
Authors: Sankar Subramanian (Author) - Griffith University
E Mohandesan (Author) - Massey University, New Zealand
C D Millar (Author) - University of Auckland, New Zealand
D M Lambert (Author) - Griffith University
Publication details: Scientific Reports, Vol.5(8703); 5
Publisher: Nature Publishing Group
Date published: 2015
DOI: 10.1038/srep08703
ISSN: 2045-2322
Copyright note: Copyright © 2015 The Authors. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder in order to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Organisation Unit: School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; School of Science, Technology and Engineering; Centre for Bioinnovation
Language: English
Record Identifier: 99451020902621
Output Type: Journal article

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Web Of Science research areas: Genetics & Heredity

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