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Published VersionCC BY-NC-ND V4.0, Open Access
Journal article
Dissociable Motivational Deficits in Pre-manifest Huntington’s Disease
Cell Reports Medicine, Vol.1(9), pp.1-9
2020
PMID: 33377123
Abstract
Motivation is characterized by a willingness to overcome both cognitive and physical effort costs. Impairments in motivation are common in striatal disorders, such as Huntington’s disease (HD), but whether these impairments are isolated to particular domains of behavior is controversial. We ask whether HD differentially affects the willingness of individuals to overcome cognitive versus physical effort. We tested 20 individuals with pre-manifest HD and compared their behavior to 20 controls. Across separate trials, participants made choices about how much cognitive or physical effort they were willing to invest for reward. Our key results were that individuals with pre-manifest HD were less willing than controls to invest cognitive effort but were no different in their overall preference for physical effort. These results cannot be explained by group differences in neuropsychological or psychiatric profiles. This dissociation of cognitive- and physical-effort-based decisions provides important evidence for separable, domain-specific mechanisms of motivation.
Details
- Title
- Dissociable Motivational Deficits in Pre-manifest Huntington’s Disease
- Authors
- Kelly J Atkins (Author) - Monash UniversitySophie C Andrews (Author) - Monash UniversityJulie C Stout (Author) - Monash UniversityTrevor T.-J Chong (Author) - Monash University
- Publication details
- Cell Reports Medicine, Vol.1(9), pp.1-9
- Publisher
- Cell Press
- Date published
- 2020
- DOI
- 10.1016/j.xcrm.2020.100152
- ISSN
- 2666-3791
- PMID
- 33377123
- Copyright note
- Copyright (c) 2020 The Authors. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
- Organisation Unit
- University of the Sunshine Coast, Queensland; Thompson Institute
- Language
- English
- Record Identifier
- 99659597602621
- Output Type
- Journal article
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