Differential gene expression identified in Uigur women cervical squamous cell carcinoma by suppression subtractive hybridization

Z Pan; S Chen; X Pan; Z Wang; H Han; W Zheng; X Wang; F Li; S Qu; Renfu Shao

doi:10.4149/neo_2010_02_123

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Differential gene expression identified in Uigur women cervical squamous cell carcinoma by suppression subtractive hybridization

Journal article

Peer reviewed

Differential gene expression identified in Uigur women cervical squamous cell carcinoma by suppression subtractive hybridization

Z Pan, S Chen, X Pan, Z Wang, H Han, W Zheng, X Wang, F Li, S Qu and Renfu Shao

Neoplasma, Vol.57(2), pp.123-128

2010

DOI: https://doi.org/10.4149/neo_2010_02_123

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Abstract

Uigur women

squamous cell carcinoma

supression

subtractive hybridization

gene expression

cervical tumor

Cervical cancer is one of the most common gynecological cancers worldwide. Over the past decade, much progress has been made in understanding the genetic changes associated with the development and progression of cervical cancer. However, the precise mechanisms of cervical carcinogenesis in Uigur women remain unclear. To screen differential gene expression in squamous cell carcinoma (SCC) of the cervix in Uigur women, suppressive subtractive hybridization (SSH) was performed on the cervical squamous cell carcinoma and corresponding normal cervical tissues of a Uigur patient. Thus we were be able to find the genes that are related with cervical tumors of Uigur women. A total of 300 samples were subject to DNA sequencing analysis and 46 genes were found to express differentially in tumors compared with normal tissues. Of the 46 genes, 24 genes were up-regulated whereas 22 genes were down-regulated in cervical tumors. The expression profiles of 5 of the 46 genes were further confirmed in 15 other Uigur patients by semi-quantitative reverse-transcription polymerase chain reaction. Our results revealed that ACADVL, CEBPB, IFITM1 and DNAJC9 are involved in cervical carcinogenesis.

Details

Title: Differential gene expression identified in Uigur women cervical squamous cell carcinoma by suppression subtractive hybridization
Authors: Z Pan (Author) - Shihezi University, China
S Chen (Author) - Shihezi University, China
X Pan (Author) - Shihezi University, China
Z Wang (Author) - Shihezi University, China
H Han (Author) - Shihezi University, China
W Zheng (Author) - Shihezi University, China
X Wang (Author) - Shihezi University, China
F Li (Author) - Shihezi University, China
S Qu (Author) - Huazhong University of Science and Technology, China
Renfu Shao (Author) - University of Queensland
Publication details: Neoplasma, Vol.57(2), pp.123-128
Publisher: Vydavatel'stvo Slovenskej Akademie Vied Veda
Date published: 2010
DOI: 10.4149/neo_2010_02_123
ISSN: 0028-2685
Organisation Unit: School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; School of Science, Technology and Engineering; Centre for Bioinnovation
Language: English
Record Identifier: 99449988802621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Oncology

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