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Accepted VersionCC BY-NC-ND V4.0, Open Access
Journal article
Differential BDNF methylation in combat exposed veterans and the association with exercise
Gene, Vol.698, pp.107-112
2019
PMID: 30831210
Abstract
Brain-derived neurotrophic factor (BDNF) gene is associated with increased risk of posttraumatic stress disorder (PTSD) and plays a role in neuroplasticity, cognition and memory. BDNF has strong potential as a therapeutic target as studies have shown that antidepressants, electroconvulsive treatment and exercise modulate BDNF expression and methylation. In this study we examined the role of BDNF methylation and expression in PTSD and the implications of exercise in mediating these effects.
BDNF DNA methylation and gene expression analysis was performed in a sample of 96 male Vietnam veterans. Cases were combat-exposed veterans with current PTSD (n = 48) and controls were combat exposed veterans with no past or current PTSD diagnosis (n = 48).
No association between BDNF mRNA and PTSD was identified. PTSD was associated with decreased methylation at three BDNF CpG sites (cg01546433 P = 0.004835; cg24650785 P = 0.000259 and cg002298481 P = 0.000672). Differential BDNF methylation was associated with exercise, with active exercise associated with lower methylation levels at three CpG sites (cg04481212 P = 0.005; cg01546433 P = 0.025 and cg00298481 P = 0.035). Given that exercise mediates BDNF action on cognitive plasticity, exercise may be a non-invasive, drug free option in the treatment of PTSD.
Details
- Title
- Differential BDNF methylation in combat exposed veterans and the association with exercise
- Authors
- Joanne Voisey (Author) - Queensland University of TechnologyBruce Lawford (Author) - Queensland University of TechnologyDagmar Bruenig (Author) - Queensland University of TechnologyWendy Harvey (Author) - Greenslopes Private HospitalCharles P Morris (Author) - Queensland University of TechnologyRoss Young (Author) - Queensland University of TechnologyDivya Mehta (Author) - Queensland University of Technology
- Publication details
- Gene, Vol.698, pp.107-112
- Publisher
- Elsevier BV
- Date published
- 2019
- DOI
- 10.1016/j.gene.2019.02.067
- ISSN
- 1879-0038; 0378-1119
- PMID
- 30831210
- Copyright note
- Copyright © 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
- Organisation Unit
- University of the Sunshine Coast, Queensland; Office of the Deputy Vice-Chancellor (Research and Innovation)
- Language
- English
- Record Identifier
- 99551000302621
- Output Type
- Journal article
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