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Differences among group A streptococcus epidemiological landscapes: consequences for M protein-based vaccines?
Journal article   Peer reviewed

Differences among group A streptococcus epidemiological landscapes: consequences for M protein-based vaccines?

P R Smeesters, David J McMillan, K S Sriprakash and M M Georgousakis
Expert Review of Vaccines, Vol.8(12), pp.1705-1720
2009
url
https://doi.org/10.1586/ERV.09.133View
Published Version

Abstract

group A streptococcus M protein M protein vaccine streptococcus pyogenes
Group A streptococcus (GAS) is a bacterial pathogen responsible for a wide array of disease pathologies in humans. GAS surface M protein plays multiple key roles in pathogenesis, and serves as a target for typing and vaccine development. In this review, we have compiled GAS epidemiological studies from several countries around the world to highlight the consequences on the theoretical efficacy of two different M protein-based vaccine strategies.

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