Determinants of heterotopic ossification after total hip replacement surgery

M Fransen; B Neal; I D Cameron; R Crawford; G Tregonning; Julie Winstanley; R Norton

doi:10.1177/112070000901900108

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Determinants of heterotopic ossification after total hip replacement surgery

Journal article

Peer reviewed

Determinants of heterotopic ossification after total hip replacement surgery

M Fransen, B Neal, I D Cameron, R Crawford, G Tregonning, Julie Winstanley and R Norton

Hip International: the journal of clinical and experimental research on hip pathology and therapy, Vol.19(1), pp.41-46

2009

DOI: https://doi.org/10.1177/112070000901900108

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Abstract

heterotopic ossification

hip replacement surgery

risk factors

The ability of various pre- or peri-operative variables to determine the risk of developing moderate to severe heterotopic ossification (HO ) six to twelve months after surgery was investigated among 407 patients undergoing elective total hip replacement (THR ) surgery and allocated to placebo in a randomised controlled trial evaluating NSA IDs-based prophylaxis for HO . Overall, 11 (30%) of the 37 patients undergoing revision surgery developed moderate to severe HO compared with 58 (16%) of the 370 patients undergoing primary THR ; odds ratio (OR ) 2.3, 95% confidence interval (CI) 1.1 to 4.9. Among patients undergoing primary THR , mutually adjusted analysis of collected independent risk factors demonstrated that receiving a transfusion of red cells or having general as well as epidural or spinal anaesthesia present as indicators of increased risk for developing moderate to severe HO . Patients who have undergone revision surgery have a significantly increased risk of clinically relevant ectopic bone, while among patients who have undergone primary THR surgery, those with indicators of excessive surgical bleeding are also at increased risk of clinically relevant HO .

Details

Title: Determinants of heterotopic ossification after total hip replacement surgery
Authors: M Fransen (Author) - University of Sydney
B Neal (Author) - University of Sydney
I D Cameron (Author) - University of Sydney
R Crawford (Author) - Queensland University of Technology
G Tregonning (Author) - Middlemore Hospital
Julie Winstanley (Author) - University of the Sunshine Coast - Faculty of Science, Health and Education
R Norton (Author) - University of Sydney
Publication details: Hip International: the journal of clinical and experimental research on hip pathology and therapy, Vol.19(1), pp.41-46
Publisher: Wichtig Editore Srl
Date published: 2009
DOI: 10.1177/112070000901900108
ISSN: 1120-7000
Organisation Unit: University of the Sunshine Coast, Queensland
Language: English
Record Identifier: 99449684002621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Orthopedics

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