Design, Development, and Testing of Polymeric Microblades: A Novel Design of Microneedles for Biomedical Applications

Vahid Ebrahiminejad; Zahra Faraji Rad

doi:10.1002/admi.202201115

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Design, Development, and Testing of Polymeric Microblades: A Novel Design of Microneedles for Biomedical Applications

Journal article

Open access

Peer reviewed

Design, Development, and Testing of Polymeric Microblades: A Novel Design of Microneedles for Biomedical Applications

Vahid Ebrahiminejad and Zahra Faraji Rad

Advanced Materials Interfaces, Vol.9(29), pp.1-16

2022

DOI: https://doi.org/10.1002/admi.202201115

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Abstract

Drug delivery

Microblade

Micromolding

Microneedle

Two-photonpolymerization

Conventional microneedles (MNs) are designed as an array of micrometer-sized projections that can painlessly penetrate the skin. Fabrication of MN arrays can be costly and time-consuming; additionally, full penetration of an array of MNs with ten to thousands of projections into the skin may not be achievable. This paper reports a new design of MNs known as microblades (MBs) which consist of a singular microstructure. The single integrated design of the MBs reduces the fabrication cost and time, facilitates more effective penetration, and may pave the way for the scale-up manufacturing of MN devices. Different designs of MBs are fabricated by two-photon polymerization technique, followed by polydimethylsiloxane micromolding and soft embossing to create replicas. The mechanical integrity of the designs is determined by a series of compression tests. Skin insertion and drug diffusion studies are conducted using a custom-made applicator to insert the MBs into the porcine abdominal skin to demonstrate delivery of fluorescein tracer. MBs insertion and penetration capabilities and the diffusion of a model drug into a multi-layered human skin are demonstrated using finite element analysis and 3D diffusion models. The results demonstrate the functional capabilities of the MBs as an alternative to MN arrays.

Details

Title: Design, Development, and Testing of Polymeric Microblades: A Novel Design of Microneedles for Biomedical Applications
Authors: Vahid Ebrahiminejad - University of Southern Queensland
Zahra Faraji Rad (Corresponding Author) - University of Southern Queensland
Publication details: Advanced Materials Interfaces, Vol.9(29), pp.1-16
Publisher: Wiley-VCH Verlag GmbH & Co. KGaA
Date published: 2022
DOI: 10.1002/admi.202201115
ISSN: 2196-7350
Copyright note: © 2022 The Authors. Advanced Materials Interfaces published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Data Availability: The data that support the findings of this study are available from the corresponding author upon reasonable request.
Organisation Unit: School of Science, Technology and Engineering
Language: English
Record Identifier: 991140404602621
Output Type: Journal article

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