Deoxyribozyme-based three-input logic gates and construction of a molecular full adder

H Lederman; Joanne Macdonald; D Stefanovic; M N Stojanovic

doi:10.1021/bi051871u

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Deoxyribozyme-based three-input logic gates and construction of a molecular full adder

Journal article

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Deoxyribozyme-based three-input logic gates and construction of a molecular full adder

H Lederman, Joanne Macdonald, D Stefanovic and M N Stojanovic

Biochemistry, Vol.45(4), pp.1194-1199

2006

DOI: https://doi.org/10.1021/bi051871u

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Abstract

Biochemistry and Cell Biology

Medical Biochemistry and Metabolomics

Medicinal and Biomolecular Chemistry

We have developed an array of seven deoxyribozyme-based molecular logic gates that behaves as a full adder in a single solution, with three oligonucleotides as inputs and two independent fluorogenic cleavage reactions as carry and sum outputs. The sum output consisted of four new deoxyribozyme-based logic gates: an ANDAND gate and three ANDNOTANDNOT gates. These gates required the design of a generic three-input deoxyribozyme-based logic gate that can use any three-way combination of activating or inactivating inputs. This generic gate design utilizes an additional inverting element that hybridizes to convert YES logic into NOT logic and vice versa. The system represents the first solution-phase, single test tube, enzymatic full adder and shows the complexity of control over molecular scale events that can be achieved with deoxyribozyme-based logic gates. Similar systems could be applied to control autonomous therapeutic and diagnostic devices.

Details

Title: Deoxyribozyme-based three-input logic gates and construction of a molecular full adder
Authors: H Lederman (Author)
Joanne Macdonald (Author) - Columbia University, United States
D Stefanovic (Author)
M N Stojanovic (Author)
Publication details: Biochemistry, Vol.45(4), pp.1194-1199
Publisher: American Chemical Society
Date published: 2006
DOI: 10.1021/bi051871u
ISSN: 0006-2960
Organisation Unit: School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; School of Science, Technology and Engineering; Centre for Bioinnovation
Language: English
Record Identifier: 99450386602621
Output Type: Journal article

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Collaboration types: Domestic collaboration
Web Of Science research areas: Biochemistry & Molecular Biology

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