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Published VersionCC BY V4.0, Open Access
Journal article
Deleterious mutation load in the admixed mice population
Frontiers in Ecology and Evolution, Vol.11, pp.1-9
2023
Abstract
Deleterious mutation loads are known to correlate negatively with effective population size (Ne). Due to this reason, previous studies observed a higher proportion of harmful mutations in small populations than that in large populations. However, the mutational load in an admixed population that derived from introgression between individuals from two populations with vastly different Ne is not known. We investigated this using the whole genome data from two subspecies of the mouse (Mus musculus castaneus and Mus musculus musculus) with significantly different Ne. We used the ratio of diversities at nonsynonymous and synonymous sites (dN/dS) to measure the harmful mutation load. Our results showed that this ratio observed for the admixed population was intermediate between those of the parental populations. The dN/dS ratio of the hybrid population was significantly higher than that of M. m. castaneus but lower than that of M. m. musculus. Our analysis revealed a significant positive correlation between the proportion of M. m. musculus ancestry in admixed individuals and their dN/dS ratio. This suggests that the admixed individuals with high proportions of M. m. musculus ancestry have large dN/dS ratios. We also used the proportion of deleterious nonsynonymous SNVs as a proxy for deleterious mutation load, which also produced similar results. The observed results were in concordance with those expected by theory. We also show a shift in the distribution of fitness effects of nonsynonymous SNVs in the admixed genomes compared to the parental populations. These findings suggest that the deleterious mutation load of the admixed population is determined by the proportion of the ancestries of the subspecies. Therefore, it is important to consider the status and the level of genetic admixture of the populations whilst estimating the mutation loads.
Details
- Title
- Deleterious mutation load in the admixed mice population
- Authors
- Umayal Ramasamy (Author) - University of the Sunshine Coast, Queensland, School of Science, Technology and EngineeringAbigail Elizur (Author) - University of the Sunshine Coast, Queensland, Centre for BioinnovationSankar Subramanian (Author) - University of the Sunshine Coast, Queensland, Centre for Bioinnovation
- Publication details
- Frontiers in Ecology and Evolution, Vol.11, pp.1-9
- Publisher
- Frontiers Research Foundation
- Date published
- 2023
- DOI
- 10.3389/fevo.2023.1084502
- ISSN
- 2296-701X
- Copyright note
- © 2023 Ramasamy, Elizur and Subramanian. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
- Organisation Unit
- School of Science, Technology and Engineering; Centre for Bioinnovation; School of Health - Public Health
- Language
- English
- Record Identifier
- 99712279102621
- Output Type
- Journal article
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