Delayed preattentional functioning in early psychosis patients with cannabis use

N Pesa; Daniel F Hermens; R A Battisti; M Kaur; I B Hickie; N Solowij

doi:10.1007/s00213-012-2676-2

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Delayed preattentional functioning in early psychosis patients with cannabis use

Journal article

Peer reviewed

Delayed preattentional functioning in early psychosis patients with cannabis use

N Pesa, Daniel F Hermens, R A Battisti, M Kaur, I B Hickie and N Solowij

Psychopharmacology, Vol.222(3), pp.507-518

2012

DOI: https://doi.org/10.1007/s00213-012-2676-2

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Abstract

cannabis

marijuana

mismatch negativity

P3a

psychosis

MMN

Rationale Cannabis use is prevalent among the early psychosis (EP) population. The event-related potentials, mismatch negativity (MMN) and P3a are reduced in EP. Cannabinoids have been shown to modulate N-methyl-Daspartate receptors which are involved in MMN generation. Objectives This study is the first to investigate the effects of cannabis use on MMN/P3a in EP. Methods EP was defined as a history of psychosis or psychotic symptoms with no progression to date to chronic schizophrenia. Twenty-two EP patients with cannabis use (EP+CANN), 22 non-cannabis-using EP patients (EPCANN) and 21 healthy controls participated in this study. MMN/P3a was elicited using a two-tone, auditory paradigm with 8% duration deviants. Results As expected, EP-CANN showed marked reductions in MMN/P3a amplitudes compared to controls. However, EP+CANN showed evidence of a different pattern of neurophysiological expression of MMN/P3a compared to nonusing patients, most notably in terms of delayed frontal MMN/P3a latencies. Conclusions This study provides further evidence that MMN/P3a deficits are present during early psychosis and suggests that this biomarker may have utility in differentiating substance- from non-substance-related psychoses. © Springer-Verlag 2012.

Details

Title: Delayed preattentional functioning in early psychosis patients with cannabis use
Authors: N Pesa (Author) - University of Wollongong
Daniel F Hermens (Author) - University of Sydney
R A Battisti (Author) - University of Sydney
M Kaur (Author) - University of Sydney
I B Hickie (Author) - University of Sydney
N Solowij (Author) - University of Wollongong
Publication details: Psychopharmacology, Vol.222(3), pp.507-518
Publisher: Springer
Date published: 2012
DOI: 10.1007/s00213-012-2676-2
ISSN: 0033-3158
Organisation Unit: University of the Sunshine Coast, Queensland; Thompson Institute
Language: English
Record Identifier: 99450510202621
Output Type: Journal article

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Collaboration types: Domestic collaboration
Web Of Science research areas: Neurosciences; Pharmacology & Pharmacy; Psychiatry

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