Degradation of differently processed Mg-based implants leads to distinct foreign body reactions (FBRs) through dissimilar signaling pathways

Xiao Song Liu; Guoqiang Chen; Xiongxiong Zhong; Tianfang Wang; Xiaohong He; Weipeng Yuan; Pingping Zhang; Ying Liu; Dongming Cao; Shu Chen; Ken-ichi Manabe; Zhengyi Jiang; Tsuyoshi Furushima; Damon Kent; Yang Chen; Guoying Ni; Mingyong Gao; Hejie Li

doi:10.1016/j.jma.2022.03.017

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Degradation of differently processed Mg-based implants leads to distinct foreign body reactions (FBRs) through dissimilar signaling pathways

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Degradation of differently processed Mg-based implants leads to distinct foreign body reactions (FBRs) through dissimilar signaling pathways

Xiao Song Liu, Guoqiang Chen, Xiongxiong Zhong, Tianfang Wang, Xiaohong He, Weipeng Yuan, Pingping Zhang, Ying Liu, Dongming Cao, Shu Chen, …

Journal of Magnesium and Alloys, Vol.11(6), pp.2106-2124

2023

DOI: https://doi.org/10.1016/j.jma.2022.03.017

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Abstract

toxicity test

proteomics analysis

signaling pathway

biocompatibility and corrosion resistance

first-order pyramidal slip system

recovery and recrystallization

foreign body reactions (FBRs)

Mg alloys have mechanical properties compatible with human bones. However, their rapid degradation and associated foreign body reactions in vivo significantly limit their application for human implants. In this study, three differently processed Mg alloys, pure Mg (PM), cold extruded Mg alloy AZ31 (CE AZ31), and fully annealed AZ31 Mg alloy (FA AZ31) were comparatively investigated for their potential as implants using a rat model. All three implanted Mg alloys do not show any impact on hepato- and renal function, nor any signs of observable changes to vital organs. Proteomics analysis of tissues directly contacting the implants 2.5 months post implantation revealed that FA AZ31 activates very few inflammation and immune associated signaling pathways; while the CE AZ31 and PM produce more significant inflammatory responses as confirmed by cytokine array analyses. Further, FA AZ31 activated pathways for cell organization and development that may improve the recovery of injured tissues. Structurally, EBSD analysis reveals that the FA AZ31 alloy has a higher ratio of first-order pyramidal orientated (10–11) {10–1–2} grain texture with a value of 0.25, while PM and CE AZ31 alloys have lower ratios of first-order pyramidal orientated texture with the values of 0.16 and 0.17, respectively. This is associated with recovery and recrystallisation during annealing which promotes grain texture which exhibits enhanced degradation behaviours and induces a more limited immune response in vivo. In conclusion, the FA AZ31 demonstrated better biocompatibility and corrosion resistance and is a promising candidate for metal-based degradable implants which warrants further investigation.

Details

Title: Degradation of differently processed Mg-based implants leads to distinct foreign body reactions (FBRs) through dissimilar signaling pathways
Authors: Xiao Song Liu (Author) - First People's Hospital of Foshan
Guoqiang Chen (Author) - First People's Hospital of Foshan
Xiongxiong Zhong (Author) - ShenZhen People’s Hospital
Tianfang Wang (Author) - University of the Sunshine Coast, Queensland, GeneCology Research Centre - Legacy
Xiaohong He (Author) - First People's Hospital of Foshan
Weipeng Yuan (Author) - First People's Hospital of Foshan
Pingping Zhang (Author) - First People's Hospital of Foshan
Ying Liu (Author) - First People's Hospital of Foshan
Dongming Cao (Author) - First People's Hospital of Foshan
Shu Chen (Author) - First People's Hospital of Foshan
Ken-ichi Manabe (Author) - Tokyo Metropolitan University
Zhengyi Jiang (Author) - University of Wollongong
Tsuyoshi Furushima (Author) - The University of Tokyo
Damon Kent (Author) - University of the Sunshine Coast, Queensland, School of Science, Technology and Engineering
Yang Chen (Corresponding Author) - First People's Hospital of Foshan
Guoying Ni (Author) - University of the Sunshine Coast, Queensland, GeneCology Research Centre - Legacy
Mingyong Gao (Corresponding Author) - First People's Hospital of Foshan
Hejie Li (Corresponding Author) - University of the Sunshine Coast, Queensland, GeneCology Research Centre - Legacy
Publication details: Journal of Magnesium and Alloys, Vol.11(6), pp.2106-2124
Publisher: Ke Ai Publishing Communications Ltd.
Date published: 2023
DOI: 10.1016/j.jma.2022.03.017
ISSN: 2213-9567
Copyright note: © 2022 Chongqing University. Publishing services provided by Elsevier B.V. on behalf of KeAi Communications Co. Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/) Peer review under responsibility of Chongqing University.
Organisation Unit: School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; GeneCology Research Centre - Legacy; School of Science, Technology and Engineering; Centre for Bioinnovation
Language: English
Record Identifier: 99637977402621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Metallurgy & Metallurgical Engineering