Deficits in episodic memory retrieval reveal impaired default mode network connectivity in amnestic mild cognitive impairment

C J Dunn; S L Duffy; I B Hickie; Jim Lagopoulos; S J G Lewis; S L Naismith; J M Shine

doi:10.1016/j.nicl.2014.02.010

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Deficits in episodic memory retrieval reveal impaired default mode network connectivity in amnestic mild cognitive impairment

Journal article

Open access

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Deficits in episodic memory retrieval reveal impaired default mode network connectivity in amnestic mild cognitive impairment

C J Dunn, S L Duffy, I B Hickie, Jim Lagopoulos, S J G Lewis, S L Naismith and J M Shine

NeuroImage: Clinical, Vol.4, pp.473-480

2014

DOI: https://doi.org/10.1016/j.nicl.2014.02.010

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Abstract

functional magnetic resonance imaging

resting state functional connectivity

mild cognitive impairment

memory

amnestic

default mode network

Amnestic mild cognitive impairment (aMCI) is believed to represent a transitional stage between normal healthy ageing and the development of dementia. In particular, aMCI patients have been shown to have higher annual transition rates to Alzheimer's Disease (AD) than individuals without cognitive impairment. Despite intensifying interest investigating the neuroanatomical basis of this transition, there remain a number of questions regarding the pathophysiological process underlying aMCI itself. A number of recent studies in aMCI have shown specific impairments in connectivity within the default mode network (DMN), which is a group of regions strongly related to episodic memory capacities. However to date, no study has investigated the integrity of the DMN between patients with aMCI and those with a non-amnestic pattern of MCI (naMCI), who have cognitive impairment, but intact memory storage systems. In this study, we contrasted the DMN connectivity in 24 aMCI and 33 naMCI patients using seed-based resting state fMRI. The two groups showed no statistical difference in their DMN intra-connectivity. However when connectivity was analysed according to performance on measures of episodic memory retrieval, the two groups were separable, with aMCI patients demonstrating impaired functional connectivity between the hippocampal formation and the posterior cingulate cortex. We provide evidence that this lack of connectivity is driven by impaired communication from the posterior cingulate hub and does not simply represent hippocampal atrophy, suggesting that posterior cingulate degeneration is the driving force behind impaired DMN connectivity in aMCI. © 2014 The Authors.

Details

Title: Deficits in episodic memory retrieval reveal impaired default mode network connectivity in amnestic mild cognitive impairment
Authors: C J Dunn (Author) - University of Sydney
S L Duffy (Author) - University of Sydney
I B Hickie (Author) - University of Sydney
Jim Lagopoulos (Author) - University of Sydney
S J G Lewis (Author) - University of Sydney
S L Naismith (Author) - University of Sydney
J M Shine (Author) - University of Sydney
Publication details: NeuroImage: Clinical, Vol.4, pp.473-480
Publisher: Elsevier BV
Date published: 2014
DOI: 10.1016/j.nicl.2014.02.010
ISSN: 2213-1582
Organisation Unit: University of the Sunshine Coast, Queensland; Thompson Institute
Language: English
Record Identifier: 99449205802621
Output Type: Journal article

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