Days out of role and somatic, anxious-depressive, hypo-manic, and psychotic-like symptom dimensions in a community sample of young adults

Jacob J Crouse; Nicholas Ho; Jan Scott; Nicholas G Martin; Baptiste Couvy-Duchesne; Daniel F Hermens; Richard Parker; Nathan A Gillespie; Sarah E Medland; Ian B Hickie

doi:10.1038/s41398-021-01390-y

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Days out of role and somatic, anxious-depressive, hypo-manic, and psychotic-like symptom dimensions in a community sample of young adults

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Days out of role and somatic, anxious-depressive, hypo-manic, and psychotic-like symptom dimensions in a community sample of young adults

Jacob J Crouse, Nicholas Ho, Jan Scott, Nicholas G Martin, Baptiste Couvy-Duchesne, Daniel F Hermens, Richard Parker, Nathan A Gillespie, Sarah E Medland and Ian B Hickie

Translational Psychiatry, Vol.11(1), pp.285-285

2021

DOI: https://doi.org/10.1038/s41398-021-01390-y

PMID: 33986245

Appears in Thompson Institute Research Collection

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Schizophrenia

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AbstractImproving our understanding of the causes of functional impairment in young people is a major global challenge. Here, we investigated the relationships between self-reported days out of role and the total quantity and different patterns of self-reported somatic, anxious-depressive, psychotic-like, and hypomanic symptoms in a community-based cohort of young adults. We examined self-ratings of 23 symptoms ranging across the four dimensions and days out of role in >1900 young adult twins and non-twin siblings participating in the “19Up” wave of the Brisbane Longitudinal Twin Study. Adjusted prevalence ratios (APR) and 95% confidence intervals (95% CI) quantified associations between impairment and different symptom patterns. Three individual symptoms showed significant associations with days out of role, with the largest association for impaired concentration. When impairment was assessed according to each symptom dimension, there was a clear stepwise relationship between the total number of somatic symptoms and the likelihood of impairment, while individuals reporting ≥4 anxious-depressive symptoms or five hypomanic symptoms had greater likelihood of reporting days out of role. Furthermore, there was a stepwise relationship between the total number of undifferentiated symptoms and the likelihood of reporting days out of role. There was some suggestion of differences in the magnitude and significance of associations when the cohort was stratified according to sex, but not for age or twin status. Our findings reinforce the development of early intervention mental health frameworks and, if confirmed, support the need to consider interventions for subthreshold and/or undifferentiated syndromes for reducing disability among young people.

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Title: Days out of role and somatic, anxious-depressive, hypo-manic, and psychotic-like symptom dimensions in a community sample of young adults
Authors: Jacob J Crouse (Author) - The University of Sydney
Nicholas Ho (Author) - The University of Sydney
Jan Scott (Author) - University of Newcastle Australia
Nicholas G Martin (Author) - QIMR Berghofer Medical Research Institute
Baptiste Couvy-Duchesne (Author) - The University of Queensland
Daniel F Hermens (Author) - University of the Sunshine Coast, Queensland, Thompson Institute
Richard Parker (Author) - QIMR Berghofer Medical Research Institute
Nathan A Gillespie (Author) - Virginia Commonwealth University
Sarah E Medland (Author) - QIMR Berghofer Medical Research Institute
Ian B Hickie (Author) - The University of Sydney
Publication details: Translational Psychiatry, Vol.11(1), pp.285-285
Publisher: Nature Publishing Group
Date published: 2021
DOI: 10.1038/s41398-021-01390-y
ISSN: 2158-3188
PMID: 33986245
Copyright note: © The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Organisation Unit: University of the Sunshine Coast, Queensland; Thompson Institute
Language: English
Record Identifier: 99533806802621
Output Type: Journal article

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