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DRD2 - ANKK1 Taq1A (rs 1800497 C - T) genotypes are associated with susceptibility to second generation antipsychotic-induced akathisia151.00 kB
Accepted VersionCC BY-NC-ND V4.0, Open Access
Journal article
DRD2/ANKK1 Taq1A (rs 1800497 C>T) genotypes are associated with susceptibility to second generation antipsychotic-induced akathisia
Journal of Psychopharmacology, Vol.27(4), pp.343-348
2013
PMID: 23118020
Abstract
Although the advent of atypical, second-generation antipsychotics (SGAs) has resulted in reduced likelihood of akathisia, this adverse effect remains a problem. It is known that extrapyramidal adverse effects are associated with increased drug occupancy of the dopamine 2 receptors (DRD2). The A1 allele of the DRD2/ANKK1, rs1800497, is associated with decreased striatal DRD2 density. The aim of this study was to identify whether the A1(T) allele of DRD2/ANKK1 was associated with akathisia (as measured by Barnes Akathisia Rating Scale) in a clinical sample of 234 patients who were treated with antipsychotic drugs. Definite akathisia (a score ≥ 2 in the global clinical assessment of akathisia) was significantly less common in subjects who were prescribed SGAs (16.8%) than those prescribed FGAs (47.6%), p < 0.0001. Overall, 24.1% of A1+ patients (A1A2/A1A1) who were treated with SGAs had akathisia, compared to 10.8% of A1- (thus, A2A2) patients. A1+ patients who were administered SGAs also had higher global clinical assessment of akathisia scores than the A1- subjects ( p = 0.01). SGAs maintained their advantage over FGAs regarding akathisia, even in A1+ patients who were treated with SGAs. These results strongly suggested that A1+ variants of the DRD2/ANKK1 Taq1A allele do confer an associated risk for akathisia in patients who were treated with SGAs, and these variants may explain inconsistencies found across prior studies, when comparing FGAs and SGAs.
Details
- Title
- DRD2/ANKK1 Taq1A (rs 1800497 C>T) genotypes are associated with susceptibility to second generation antipsychotic-induced akathisia
- Authors
- Bruce R Lawford (Author) - Queensland University of TechnologyMark Barnes (Author) - Royal Brisbane and Women's HospitalChristopher D Swagell (Author) - Queensland University of TechnologyJason P Connor (Author) - The University of QueenslandS C Burton (Author) - Royal Brisbane and Women's HospitalK Heslop (Author) - Curtin UniversityJ Voisey (Author) - Queensland University of TechnologyC P Morris (Author) - Queensland University of TechnologyP Nyst (Author) - Royal Brisbane and Women's HospitalErnest P Noble (Author) - University of California Los AngelesRoss Young (Author) - Queensland University of Technology
- Publication details
- Journal of Psychopharmacology, Vol.27(4), pp.343-348
- Publisher
- Sage Publications Ltd.
- Date published
- 2013
- DOI
- 10.1177/0269881112463469
- ISSN
- 1461-7285; 0269-8811
- PMID
- 23118020
- Copyright note
- Copyright (c) 2013. The author accepted version is available here in accordance with the publisher's copyright policy. The final definitive version: BR Lawford, M Barnes, CD Swagell, JP Connor, SC Burton, K Heslop, J Voisey, CP Morris, P Nyst, EP Noble, RM Young, DRD2/ANKK1 Taq1A (rs 1800497 C>T) genotypes are associated with susceptibility to second generation antipsychotic-induced akathisia, Journal of Psychopharmacology (27, 4) pp. 343-348. DOI: 10.1177/0269881112463469
- Organisation Unit
- University of the Sunshine Coast, Queensland; Office of the Deputy Vice-Chancellor (Research and Innovation)
- Language
- English
- Record Identifier
- 99550999002621
- Output Type
- Journal article
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