Journal article
DRD2 C957T and TaqIA Genotyping Reveals Gender Effects and Unique Low-Risk and High-Risk Genotypes in Alcohol Dependence
Alcohol and Alcoholism, Vol.47(4), pp.397-403
2012
PMID: 22582185
Abstract
Aims: As recent conflicting reports describe a genetic association between both the C-and the T-alleles of the dopa-mine D2 receptor (DRD2) C957T polymorphism (rs6277) in alcohol-dependent subjects, our aim was to examine this polymorphism and TaqIA (rs1800497) in Australian alcohol-dependent subjects. Methods: The C957T polymorphism was genotyped in 228 patients with alcohol dependence (72 females and 156 males) and 228 healthy controls. Results: The C-allele and C/C genotype of C957T was associated with alcohol dependence, whereas the TaqIA polymorphism was not. When analysed separately for C957T, males showed an even stronger association with the C-allele and females showed no association. The C957T and TaqIA haplotyping revealed a strong association with alcohol dependence and a double-genotype analysis (combining C957T and TaqIA genotypes) revealed that the relative risk of different genotypes varied by up to 27-fold with the TT/A1A2 having an 8.5-fold lower risk of alcohol dependence than other genotypes. Conclusion: Decreased DRD2 binding associated with the C-allele of the DRD2 C957T polymorphism is likely to be important in the underlying pathophysiology of at least some forms of alcohol dependence, and this effect appears to be limited to males only.
Details
- Title
- DRD2 C957T and TaqIA Genotyping Reveals Gender Effects and Unique Low-Risk and High-Risk Genotypes in Alcohol Dependence
- Authors
- Christopher D Swagell (Author) - Queensland University of TechnologyBruce R Lawford (Author) - Queensland University of TechnologyIan P Hughes (Author) - Queensland University of TechnologyJoanne Voisey (Author) - Queensland University of TechnologyGerald F X Feeney (Author) - Princess Alexandra HospitalAngela van Daal (Author) - Queensland University of TechnologyJason P Connor (Author) - Princess Alexandra HospitalErnest P Noble (Author) - University of California Los AngelesC Phillip Morris (Author) - Queensland University of TechnologyRoss Young (Author) - Queensland University of Technology
- Publication details
- Alcohol and Alcoholism, Vol.47(4), pp.397-403
- Publisher
- Oxford University Press
- Date published
- 2012
- DOI
- 10.1093/alcalc/ags047
- ISSN
- 1464-3502; 0735-0414
- PMID
- 22582185
- Copyright note
- Copyright (c) 2012. This is a pre-copyedited, author-produced version of an article accepted for publication in Alcohol and Alcoholism following peer review. The version of record Christopher D. Swagell, Bruce R. Lawford, Ian P. Hughes, Joanne Voisey, Gerald F.X. Feeney, Angela van Daal, Jason P. Connor, Ernest P. Noble, C. Phillip Morris, Ross McD. Young, DRD2 C957T and TaqIA Genotyping Reveals Gender Effects and Unique Low-Risk and High-Risk Genotypes in Alcohol Dependence, Alcohol and Alcoholism, Volume 47, Issue 4, July/August 2012, Pages 397–403, https://doi.org/10.1093/alcalc/ags047 is available online at: https://doi.org/10.1093/alcalc/ags047
- Organisation Unit
- University of the Sunshine Coast, Queensland; Office of the Deputy Vice-Chancellor (Research and Innovation)
- Language
- English
- Record Identifier
- 99550999302621
- Output Type
- Journal article
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