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Accepted VersionCC BY-NC-ND V4.0, Open Access
Journal article
DNA methylation from germline cells in veterans with PTSD
Journal of Psychiatric Research, Vol.116, pp.42-50
2019
PMID: 31195163
Abstract
In this study we investigated genome-wide sperm DNA methylation patterns in trauma-exposed Vietnam veterans. At the genome-wide level, we identified 3 CpG sites associated with PTSD in sperm including two intergenic and one CpG within the CCDC88C gene. Of those associated with PTSD in sperm at a nominal level, 1868 CpGs were also associated with PTSD in peripheral blood (5.6% overlap) including the RORA, CRHR1 and DOCK2 genes that have been previously implicated in PTSD. A total of 10 CpG sites were significantly associated with a reported history of a diagnosed mental health condition in children and reached genome-wide significance. CpGs associated with a history of a reported mental health condition in children were also enriched (90% of tested genes) for genes previously reported to be resistant to demethylation, making them strong candidates for transgenerational inheritance. In conclusion, our findings identify a unique sperm-specific DNA methylation pattern that is associated with PTSD.
Details
- Title
- DNA methylation from germline cells in veterans with PTSD
- Authors
- Divya Mehta (Author) - Queensland University of TechnologyElise S Pelzer (Author) - Queensland University of TechnologyDagmar Bruenig (Author) - Queensland University of TechnologyBruce Lawford (Author) - Queensland University of TechnologySarah McLeay (Author) - Greenslopes Private HospitalCharles P Morris (Author) - Queensland University of TechnologyJohn Gibson (Author) - Greenslopes Private HospitalRoss Young (Author) - Queensland University of TechnologyJoanne Voisey (Author) - Queensland University of Technology
- Contributors
- PTSD Initiative (Research Group)
- Publication details
- Journal of Psychiatric Research, Vol.116, pp.42-50
- Publisher
- Elsevier Ltd
- Date published
- 2019
- DOI
- 10.1016/j.jpsychires.2019.06.001
- ISSN
- 1879-1379; 0022-3956
- PMID
- 31195163
- Copyright note
- Copyright © 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
- Organisation Unit
- University of the Sunshine Coast, Queensland; Office of the Deputy Vice-Chancellor (Research and Innovation)
- Language
- English
- Record Identifier
- 99551000102621
- Output Type
- Journal article
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- Domestic collaboration
- Web Of Science research areas
- Psychiatry
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Source: InCites