D2 dopamine receptor and GABA A receptor β3 subunit genes and alcoholism

Ernest P Noble; Xuxian Zhang; Terry Ritchie; Bruce R Lawford; Stella C Grosser; Ross Young; Robert S Sparkes

doi:10.1016/S0165-1781(98)00084-5

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D2 dopamine receptor and GABA A receptor β3 subunit genes and alcoholism

Journal article

Peer reviewed

D2 dopamine receptor and GABA A receptor β3 subunit genes and alcoholism

Ernest P Noble, Xuxian Zhang, Terry Ritchie, Bruce R Lawford, Stella C Grosser, Ross Young and Robert S Sparkes

Psychiatry Research, Vol.81(2), pp.133-147

1998

DOI: https://doi.org/10.1016/S0165-1781(98)00084-5

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Abstract

Genetics

Alcoholism

GABA Aβ3

Association analysis

Severity

DRD2

As the dopaminergic and GABAergic systems have been implicated in alcohol-related behaviors, variants of the D2 dopamine receptor (DRD2) and GABAA receptor β3 subunit (GABRB3) genes were determined in a population-based association study of Caucasian non-alcoholic and alcoholic subjects. In severe alcoholics, compared to non-alcoholics, a significant increase was found in the prevalence (P=1.7×10−5) and frequency (P=1.6×10−5) of the DRD2 minor (A1) allele. Moreover, a significant progressive increase was observed in A1 allelic prevalence (P=3.1×10−6) and frequency (P=2.7×10−6) in the order of non-alcoholics, less severe and severe alcoholics. In severe alcoholics, compared to non-alcoholics, a significant decrease was found in the prevalence (P=4.5×10−3) and frequency (P=2.7×10−2) of the GABRB3 major (G1) allele. Furthermore, a significant progressive decrease was noted in G1 allelic prevalence (P=2.4×10−3) and frequency (P=1.9×10−2) in non-alcoholics, less severe and severe alcoholics, respectively. In sum, in the same population of non-alcoholics and alcoholics studied, variants of both the DRD2 and GABRB3 genes independently contribute to the risk for alcoholism, with the DRD2 variants revealing a stronger effect than the GABRB3 variants. However, when the DRD2 and the GABRB3 variants are combined, the risk for alcoholism is more robust than when these variants are considered separately.

Details

Title: D2 dopamine receptor and GABA A receptor β3 subunit genes and alcoholism
Authors: Ernest P Noble (Author) - UCLA Neuropsychiatric Institute
Xuxian Zhang (Author) - UCLA Neuropsychiatric Institute
Terry Ritchie (Author) - UCLA Neuropsychiatric Institute
Bruce R Lawford (Author) - University of Queensland
Stella C Grosser (Author) - UCLA Neuropsychiatric Institute
Ross Young (Author) - University of Queensland
Robert S Sparkes (Author) - University of California Los Angeles
Publication details: Psychiatry Research, Vol.81(2), pp.133-147
Publisher: Elsevier Ireland Ltd.
DOI: 10.1016/S0165-1781(98)00084-5
ISSN: 1872-7123
Organisation Unit: Office of the Deputy Vice-Chancellor (Research and Innovation); University of the Sunshine Coast, Queensland
Language: English
Record Identifier: 99551001402621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Psychiatry

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