Cytotoxic cyclic depsipeptides from the Australian marine sponge Neamphius huxleyi

Trong D Tran; N B Pham; G Fechner; D Zencak; H T Vu; J N A Hooper; R J Quinn

doi:10.1021/np3006474

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Cytotoxic cyclic depsipeptides from the Australian marine sponge Neamphius huxleyi

Journal article

Peer reviewed

Cytotoxic cyclic depsipeptides from the Australian marine sponge Neamphius huxleyi

Trong D Tran, N B Pham, G Fechner, D Zencak, H T Vu, J N A Hooper and R J Quinn

Journal of Natural Products, Vol.75(12), pp.2200-2208

2012

DOI: https://doi.org/10.1021/np3006474

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Abstract

Three new cyclic depsipeptides, neamphamides B (2), C (3), and D (4), were isolated from the Australian sponge Neamphius huxleyi. The planar structural characterization of these molecules was elucidated using 2D NMR experiments and ESI-FTICR-MSn. Their configurations were determined by Marfey's method and J-based NMR analysis. These new metabolites inhibited the growth of human cell lines (A549, HeLa, LNCaP, PC3, and NFF) with IC50 values ranging from 88 to 370 nM. However, neamphamide D causes A549 cell proliferation at subcytotoxic doses and should be treated cautiously as a cytotoxic compound. © 2012 The American Chemical Society and American Society of Pharmacognosy.

Details

Title: Cytotoxic cyclic depsipeptides from the Australian marine sponge Neamphius huxleyi
Authors: Trong D Tran (Author) - Griffith University
N B Pham (Author) - Griffith University
G Fechner (Author) - Griffith University
D Zencak (Author) - Griffith University
H T Vu (Author) - Griffith University
J N A Hooper (Author) - Griffith University
R J Quinn (Author) - Griffith University
Publication details: Journal of Natural Products, Vol.75(12), pp.2200-2208
Publisher: American Chemical Society
Date published: 2012
DOI: 10.1021/np3006474
ISSN: 0163-3864
Organisation Unit: School of Science and Engineering - Legacy; University of the Sunshine Coast, Queensland; School of Science, Technology and Engineering; Centre for Bioinnovation
Language: English
Record Identifier: 99450342702621
Output Type: Journal article

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