Cytotoxic Activity and Phytochemical Constituents of Macrosolen bidoupensis Tangane & V.S. Dang

Kieu Hung Le; Tran Canh Nguyen; The Anh Nguyen; Nu Dan Phuong Nguyen; Thi Hong Tuoi Do; Le Thanh Tuyen Nguyen; Van Son Dang; Trong Duc Tran; Nhat Minh Phan; Trong Dat Bui; Dinh Tri Mai; Nguyen Tan Phat

doi:10.25135/rnp.197.20.02.1545

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Cytotoxic Activity and Phytochemical Constituents of Macrosolen bidoupensis Tangane & V.S. Dang

Journal article

Peer reviewed

Cytotoxic Activity and Phytochemical Constituents of Macrosolen bidoupensis Tangane & V.S. Dang

Kieu Hung Le, Tran Canh Nguyen, The Anh Nguyen, Nu Dan Phuong Nguyen, Thi Hong Tuoi Do, Le Thanh Tuyen Nguyen, Van Son Dang, Trong Duc Tran, Nhat Minh Phan, Trong Dat Bui, …

Records of Natural Products, Vol.15(1), pp.71-75

2021

DOI: https://doi.org/10.25135/rnp.197.20.02.1545

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Abstract

Macrosolen bidoupensis

Loranthaceae

cytotoxic activity

triterpenoid

steroid

Phytochemical investigations of the whole plants of Macrosolen bidoupensis Tangane & V.S. Dang, a new species discovered in Viet Nam were conducted and led to the purification of ten compounds, comprising three lupane-type (1-3), three friedelane-type (4-6), and one glutinane-type (7) triterpenoids and three cholestane-type steroids (8-10) using various chromatographic methods. Their structures were characterized by HR-ESI-MS, NMR experiments and comparison with previous literature. Compounds 1, 3 and 5 expressed moderate cytotoxicity against two tested cell lines - MDA-MB-231 and RD (IC50 ranged from 34.19 to 74.25 μM), whereas compounds 4 and 6 exhibited selective cytotoxic activity (IC50 ranged from 29.07 to 45.20 μM).

Details

Title: Cytotoxic Activity and Phytochemical Constituents of Macrosolen bidoupensis Tangane & V.S. Dang
Authors: Kieu Hung Le (Author) - Vietnam Academy of Science and Technology
Tran Canh Nguyen (Author) - Vietnam Academy of Science and Technology
The Anh Nguyen (Author) - Bui Thi Xuan High School
Nu Dan Phuong Nguyen (Author) - Tran Phu High School
Thi Hong Tuoi Do (Author) - University of Medicine and Pharmacy
Le Thanh Tuyen Nguyen (Author) - University of Medicine and Pharmacy
Van Son Dang (Author) - Vietnam Academy of Science and Technology
Trong Duc Tran (Author) - University of the Sunshine Coast, Queensland, School of Science and Engineering - Legacy
Nhat Minh Phan (Author) - Vietnam Academy of Science and Technology
Trong Dat Bui (Author) - Vietnam Academy of Science and Technology
Dinh Tri Mai (Author) - Vietnam Academy of Science and Technology
Nguyen Tan Phat (Author) - Vietnam Academy of Science and Technology
Publication details: Records of Natural Products, Vol.15(1), pp.71-75
Publisher: A C G Publications
DOI: 10.25135/rnp.197.20.02.1545
Organisation Unit: Centre for Bioinnovation; School of Science and Engineering - Legacy; School of Science, Technology and Engineering; University of the Sunshine Coast, Queensland
Language: English
Record Identifier: 99480008402621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Chemistry, Applied; Chemistry, Medicinal; Plant Sciences

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