Cytomegalovirus in Australian blood donors: Seroepidemiology and seronegative red blood cell component inventories

D V Lancini; Helen M Faddy; S Ismay; S Chesneau; C Hogan; R L Flower

doi:10.1111/trf.13459

Back

Cytomegalovirus in Australian blood donors: Seroepidemiology and seronegative red blood cell component inventories

Journal article

Peer reviewed

Cytomegalovirus in Australian blood donors: Seroepidemiology and seronegative red blood cell component inventories

D V Lancini, Helen M Faddy, S Ismay, S Chesneau, C Hogan and R L Flower

Transfusion, Vol.56(6, Part 2), pp.1616-1621

2016

DOI: https://doi.org/10.1111/trf.13459

Files and links (1)

url

https://doi.org/10.1111/trf.13459View

Published Version

Abstract

Cardiovascular Medicine and Haematology

Clinical Sciences

Immunology

BACKGROUND: Cytomegalovirus (CMV) can lead to severe disease in high-risk subpopulations. To prevent transfusion-transmitted CMV in these patient groups, the Australian Red Cross Blood Service maintains inventories of CMV-seronegative fresh blood components. STUDY DESIGN AND METHODS: Donor demographic data and CMV seroscreening results for all blood donations and blood components issued in Australia between financial years (FYs) 2008/09 to 2012/13 inclusive were obtained. Population estimates were also extracted for the calculation of age-weighted seroprevalence estimates. Linear regression was used to model trends in red blood cell (RBC) component acquisition and demand. RESULTS: The estimated age-weighted seroprevalence of CMV in 20-to 69-year old Australians was 76.12±0.13%, with higher seroprevalence in females and older age groups. Seroprevalence decreased over the study period, while the demand for CMV-seronegative RBC components increased. It was predicted that component acquisition may be insufficient by FY 2017/18 if current trends persist. CONCLUSION: These findings represent an evaluation of CMV seroepidemiology in Australia and form a basis to predict the future status of CMV-seronegative RBC component inventories. The results will serve to guide Blood Service operations and inform current international debate on CMV-safe blood components.

Details

Title: Cytomegalovirus in Australian blood donors: Seroepidemiology and seronegative red blood cell component inventories
Authors: D V Lancini (Author) - University of Queensland
Helen M Faddy (Author) - University of Queensland
S Ismay (Author) - Australian Red Cross Blood Service
S Chesneau (Author) - Australian Red Cross Blood Service
C Hogan (Author) - Australian Red Cross Blood Service
R L Flower (Author) - Australian Red Cross Blood Service
Publication details: Transfusion, Vol.56(6, Part 2), pp.1616-1621
Publisher: Wiley-Blackwell Publishing Inc.
Date published: 2016
DOI: 10.1111/trf.13459
ISSN: 0041-1132
Organisation Unit: School of Health - Biomedicine; University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy; School of Health and Behavioural Sciences - Legacy
Language: English
Record Identifier: 99451352502621
Output Type: Journal article

Metrics

59 Record Views

9 Times Cited - Web of Science

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Collaboration types: Domestic collaboration
Web Of Science research areas: Hematology

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

Source: InCites