Journal article
Cytomegalovirus disease in immunocompetent adults
Medical Journal of Australia, Vol.201(10), pp.578-580
2014
PMID: 25390262
Abstract
Cytomegalovirus (CMV) is a highly prevalent and globally distributed virus. CMV infection in healthy adults is usually asymptomatic or causes a mild mononucleosis-like syndrome. CMV disease causes significant morbidity and mortality in neonates and severely immunocompromised adults. CMV disease can present with a wide range of manifestations, with colitis being the most common. The incidence of severe CMV disease in immunocompetent adults appears to be greater than previously thought, which may be partly due to immune dysfunction related to comorbidities such as kidney disease or diabetes mellitus. CMV disease can mimic an array of alternative diagnoses and pose a significant diagnostic challenge, especially in immunocompetent adults, leading to delayed diagnosis, adverse health outcomes and unnecessary financial expense. Non-invasive testing for CMV is widely available and can facilitate early diagnosis if used appropriately. Although limited, current evidence suggests that targeted antiviral therapy with ganciclovir or valganciclovir is appropriate for severe CMV disease in immunocompetent adults.
Details
- Title
- Cytomegalovirus disease in immunocompetent adults
- Authors
- Daniel Lancini (Author) - University of QueenslandHelen Faddy (Author) - Australian Red Cross Blood ServiceRobert Flower (Author) - Australian Red Cross Blood ServiceC Hogan (Author) - Australian Red Cross Blood Service
- Publication details
- Medical Journal of Australia, Vol.201(10), pp.578-580
- Publisher
- Wiley-Blackwell Publishing Asia
- DOI
- 10.5694/mja14.00183
- ISSN
- 1326-5377
- PMID
- 25390262
- Organisation Unit
- School of Health and Behavioural Sciences - Legacy; School of Health and Sport Sciences - Legacy; School of Health - Biomedicine
- Language
- English
- Record Identifier
- 99477804802621
- Output Type
- Journal article
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- Domestic collaboration
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- Infectious Diseases
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Source: InCites