Cytokine Responses to Acute Exercise in Healthy Older Adults: The Effect of Cardiorespiratory Fitness

Mark Windsor; Tom G Bailey; Maria-Christina Perissiou; Lara T Meital; Jonathan Golledge; Fraser D Russell; Christopher D Askew

doi:10.3389/fphys.2018.00203

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Cytokine Responses to Acute Exercise in Healthy Older Adults: The Effect of Cardiorespiratory Fitness

Journal article

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Cytokine Responses to Acute Exercise in Healthy Older Adults: The Effect of Cardiorespiratory Fitness

Mark Windsor, Tom G Bailey, Maria-Christina Perissiou, Lara T Meital, Jonathan Golledge, Fraser D Russell and Christopher D Askew

Frontiers in Physiology, Vol.9, pp.1-8

2018

DOI: https://doi.org/10.3389/fphys.2018.00203

PMCID: PMC5862854

PMID: 29599722

Appears in UniSC Supported Open Access Outputs

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Abstract

Markers of chronic inflammation increase with aging, and are associated with cardiovascular disease prevalence and mortality. Increases in fitness with exercise training have been associated with lower circulating concentrations of cytokines known to have pro-inflammatory actions (such as interleukin-6 [IL-6]) and higher circulating concentrations of anti-inflammatory cytokines (interleukin-10 [IL-10]). However, the effect of cardiorespiratory fitness on acute cytokine responses to a single bout of exercise in healthy older individuals is unknown. We compared the response of plasma cytokines IL-6, tumor necrosis factor-alpha (TNF-α) and IL-10 to a bout of moderate-intensity continuous and higher-intensity interval exercise between older individuals with higher and lower levels of cardiorespiratory fitness. Sixteen lower-fit (VO2peak: 22.6±2.8 mL.kg-1.min-1) and fourteen higher-fit participants (VO2peak: 37.4±5.9 mL.kg-1.min-1) completed three 24 min experimental protocols in a randomized order: (1) moderate-intensity continuous exercise (40% of peak power output [PPO]); (2) higher-intensity interval exercise (12 × 1 min intervals at 70% PPO separated by 1 min periods at 10% PPO); or (3) non-exercise control. Plasma cytokines were measured at rest, immediately after, and during 90 min of recovery following exercise or control. Plasma IL-6 concentrations at baseline were greater in the higher-fit compared to the lower-fit group (P = 0.02), with no difference in plasma IL-10 or TNF-α concentrations at baseline between groups. Plasma IL-6 and IL-10 concentrations in both groups increased immediately after all protocols (IL-6: P = 0.02, IL-10: P < 0.01). However, there was no difference in the IL-6 and IL-10 response between the exercise and non-exercise (control) protocols. After all protocols, no changes in plasma TNF-α concentrations were observed in either the higher- or lower-fit groups. In this study, basal concentrations of circulating IL-6 were elevated in older individuals with higher levels of cardiorespiratory fitness. However, changes in plasma cytokine concentrations after exercise were not different to changes after non-exercise control in both the lower- and higher-fit groups.

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Title: Cytokine Responses to Acute Exercise in Healthy Older Adults: The Effect of Cardiorespiratory Fitness
Authors: Mark Windsor (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
Tom G Bailey (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
Maria-Christina Perissiou (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
Lara T Meital (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
Jonathan Golledge (Author) - James Cook University
Fraser D Russell (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
Christopher D Askew (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
Publication details: Frontiers in Physiology, Vol.9, pp.1-8
Publisher: Frontiers Research Foundation
Date published: 2018
DOI: 10.3389/fphys.2018.00203
ISSN: 1664-042X
PMID: 29599722; PMC5862854
Copyright note: Copyright © 2018 Windsor, Bailey, Perissiou, Meital, Golledge, Russell and Askew. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Grants: National Centre of Research Excellence to Improve Management of Peripheral Arterial Disease, 1000967, National Health and Medical Research Council (Australia, Canberra) - NHMRC
Developing improved management for peripheral artery diseases, 1117061, National Health and Medical Research Council (Australia, Canberra) - NHMRC
Organisation Unit: School of Health - Biomedicine; UniSC Clinical Trials Centre; School of Health and Sport Sciences - Legacy; School of Health - Sports & Exercise Science; Centre for Bioinnovation; School of Health and Behavioural Sciences - Legacy
Language: English
Record Identifier: 99450995302621
Output Type: Journal article

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