Cyclodextrins: A Weapon in the Fight Against Antimicrobial Resistance

Chew E Wong; Anton V Dolzhenko; Sui Mae Lee; David James Young

doi:10.1142/S2251237317400068

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Cyclodextrins: A Weapon in the Fight Against Antimicrobial Resistance

Journal article

Peer reviewed

Cyclodextrins: A Weapon in the Fight Against Antimicrobial Resistance

Chew E Wong, Anton V Dolzhenko, Sui Mae Lee and David James Young

Journal of Molecular and Engineering Materials, Vol.5(1)

2017

DOI: https://doi.org/10.1142/S2251237317400068

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Abstract

Medicinal and Biomolecular Chemistry

Medical Microbiology

cyclodextrins

antimicrobial

inclusion complex

antibiotics

mechanism of action

Antimicrobial resistance poses one of the most serious global challenges of our age. Cyclodextrins (CDs) are widely utilized excipients in formulations because of their solubilizing properties, low toxicity, and low inflammatory response. This review summarizes recent investigations of antimicrobial agents involving CDs and CD-based antimicrobial materials. CDs have been employed for antimicrobial applications either through formation of inclusion complexes or by chemical modification of their hydroxyl groups to tailor pharmaceutically active compounds. Applications of these CD inclusion complexes include drug delivery, antimicrobial coatings on materials (e.g., biomedical devices and implants) and antimicrobial dressings that help to prevent wound infections. There are relatively limited studies of chemically modified CDs with antimicrobial activity. The mechanism of action of antimicrobial CD inclusion complexes and derivatives needs further elucidation, but activity of CDs and their derivatives is often associated with their interaction with bacterial cell membranes.

Details

Title: Cyclodextrins: A Weapon in the Fight Against Antimicrobial Resistance
Authors: Chew E Wong (Author) - Monash University Malaysia, Malaysia
Anton V Dolzhenko (Author) - Monash University Malaysia, Malaysia
Sui Mae Lee (Author) - Monash University Malaysia, Malaysia
David James Young (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
Publication details: Journal of Molecular and Engineering Materials, Vol.5(1); 9
Publisher: World Scientific Publishing Co. Pty. Ltd.
Date published: 2017
DOI: 10.1142/S2251237317400068
ISSN: 2251-2373
Organisation Unit: University of the Sunshine Coast, Queensland
Language: English
Record Identifier: 99450479302621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Materials Science, Multidisciplinary

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