Cutaneous markers of photo-damage and risk of basal cell carcinoma of the skin: A meta-analysis

M Khalesi; D C Whiteman; S A R Doi; J Clark; Michael G Kimlin; R E Neale

doi:10.1158/1055-9965.EPI-13-0424

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Cutaneous markers of photo-damage and risk of basal cell carcinoma of the skin: A meta-analysis

Journal article

Open access

Peer reviewed

Cutaneous markers of photo-damage and risk of basal cell carcinoma of the skin: A meta-analysis

M Khalesi, D C Whiteman, S A R Doi, J Clark, Michael G Kimlin and R E Neale

Cancer Epidemiology Biomarkers and Prevention, Vol.22(9), pp.1483-1489

2013

DOI: https://doi.org/10.1158/1055-9965.EPI-13-0424

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Abstract

basal cell carcinoma

Epidemiologic research has shown that cutaneous markers of photo-damage are associated with risk of basal cell carcinoma (BCC). However, there has been no previous attempt to calculate pooled risk estimates. We conducted a systematic review and meta-analysis after extracting relevant studies published up to January 2013 from five electronic databases. Eligible studies were those that permitted quantitative assessment of the association between histologically confirmed BCC and actinic keratoses, solar elastosis, solar lentigines, or telangiectasia. Seven eligible studies were identified and summary odds ratios (ORs) were calculated using both random and quality effects models. Having more than ten actinic keratoses was most strongly associated with BCC, conferring up to a fivefold increase in risk (OR: 4.97; 95% CI: 3.26-7.58). Other factors, including solar elastosis, solar lentigines, and telangiectasia had weaker but positive associations with BCC with ORs around 1.5. Markers of chronic photo-damage are positively associated with BCC. The presence of actinic keratoses was the most strongly associated with BCC of the markers examined. This work highlights the relatively modest association between markers of chronic ultraviolet exposure and BCC. © 2013 AACR.

Details

Title: Cutaneous markers of photo-damage and risk of basal cell carcinoma of the skin: A meta-analysis
Authors: M Khalesi (Author) - Queensland University of Technology
D C Whiteman (Author) - Queensland Institute of Medical Research
S A R Doi (Author) - University of Queensland
J Clark (Author) - University of Queensland
Michael G Kimlin (Author) - Queensland University of Technology
R E Neale (Author) - Queensland Institute of Medical Research
Publication details: Cancer Epidemiology Biomarkers and Prevention, Vol.22(9), pp.1483-1489
Publisher: American Association for Cancer Research
Date published: 2013
DOI: 10.1158/1055-9965.EPI-13-0424
ISSN: 1055-9965
Copyright note: Copyright © 2013 The Authors. The accepted manuscript is reproduced in accordance with the copyright policy of the publisher. The final version is available at http://dx.doi.org/10.1158/1055-9965.EPI-13-0424
Organisation Unit: University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy
Language: English
Record Identifier: 99449261502621
Output Type: Journal article

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Web Of Science research areas: Oncology; Public, Environmental & Occupational Health

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