Custom extraction of macular ganglion cell-inner plexiform layer thickness more precisely co-localizes structural measurements with visual fields test grids

Janelle Tong; David Alonso-Caneiro; Nayuta Yoshioka; Michael Kalloniatis; Barbara Zangerl

doi:10.1038/s41598-020-75599-0

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Custom extraction of macular ganglion cell-inner plexiform layer thickness more precisely co-localizes structural measurements with visual fields test grids

Journal article

Open access

Peer reviewed

Custom extraction of macular ganglion cell-inner plexiform layer thickness more precisely co-localizes structural measurements with visual fields test grids

Janelle Tong, David Alonso-Caneiro, Nayuta Yoshioka, Michael Kalloniatis and Barbara Zangerl

Scientific Reports, Vol.10, pp.1-13

2020

DOI: https://doi.org/10.1038/s41598-020-75599-0

PMID: 33116253

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Abstract

eye manifestations

retina

We aimed to evaluate methods of extracting optical coherence tomography (OCT)-derived macular ganglion cell-inner plexiform layer (GCIPL) thickness measurements over retinal locations corresponding to standard visual field (VF) test grids. A custom algorithm was developed to automatically extract GCIPL thickness measurements from locations corresponding to Humphrey Field Analyser 10-2 and 30-2 test grids over Goldmann II, III and V stimulus sizes from a healthy cohort of 478 participants. Differences between GCIPL thickness measurements based on VF test grids (VF-based paradigms) and the 8 × 8 grid, as per instrument review software, were analyzed, as were impacts of fovea to optic disc tilt and areas over which GCIPL thickness measurements were extracted. Significant differences between the VF-based paradigms and the 8 × 8 grid were observed at up to 55% of locations across the macula, with the greatest deviations at the fovea (median 25.5 μm, 95% CI 25.24-25.72 μm, P < .0001). While significant correlations with fovea to optic disc tilt were noted at up to 33% of locations distributed 6°-8° from the foveal center, there were no marked differences in GCIPL thickness measurements between VF-based paradigms using different stimulus sizes. As such, standard high-density OCT measurement paradigms do not adequately reflect GCIPL measurements at retinal locations tested with standard VF patterns, with the central macular region contributing most to the observed differences and with further correction required for fovea to optic disc tilt. Spatial direction of GCIPL thickness measurements will improve future comparisons of structure and function, thereby improving methods designed to detect pathology affecting the inner retina.

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Title: Custom extraction of macular ganglion cell-inner plexiform layer thickness more precisely co-localizes structural measurements with visual fields test grids
Authors: Janelle Tong (Author) - UNSW Sydney
David Alonso-Caneiro (Author) - Queensland University of Technology
Nayuta Yoshioka (Author) - UNSW Sydney
Michael Kalloniatis (Author) - UNSW Sydney
Barbara Zangerl (Corresponding Author) - UNSW Sydney
Publication details: Scientific Reports, Vol.10, pp.1-13
Publisher: Nature Publishing Group
Date published: 2020
DOI: 10.1038/s41598-020-75599-0
ISSN: 2045-2322
PMID: 33116253
Copyright note: © The Author(s) 2020. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons .org/licenses/by/4.0/.
Grant note: This work was supported by the National Health and Medical Research Council of Australia Ideas Grant [NHMRC 1186915]. Guide Dogs NSW/ACT supported this work through salary support for JT, MK and BZ and their support to clinical service delivery at the Centre for Eye Health. The funding body had no role in the conceptualization or writing of the paper. MK holds a patent on visual field test size and disease detection: International Publication Number WO2014/094035 A1(USA) and European Patent Number 13865419.9.
Organisation Unit: School of Science, Technology and Engineering
Language: English
Record Identifier: 99972396102621
Output Type: Journal article

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