Current challenges of severe acute respiratory syndrome coronavirus 2 seroprevalence studies among blood donors: A scoping review

Sahar Saeed; Samra Uzicanin; Antoine Lewin; Ryanne Lieshout‐Krikke; Helen Faddy; Christian Erikstrup; Carla Osiowy; Clive R Seed; Whitney R Steele; Katy Davison; Brian Custer; Sheila F O'Brien; Surveillance Risk Assessment and Policy (SRAP) Sub‐group of the Transfusion Transmitted Infectious Diseases Working Party of the International Society of Blood Transfusion

doi:10.1111/vox.13221

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Current challenges of severe acute respiratory syndrome coronavirus 2 seroprevalence studies among blood donors: A scoping review

Journal article

Peer reviewed

Current challenges of severe acute respiratory syndrome coronavirus 2 seroprevalence studies among blood donors: A scoping review

Sahar Saeed, Samra Uzicanin, Antoine Lewin, Ryanne Lieshout‐Krikke, Helen Faddy, Christian Erikstrup, Carla Osiowy, Clive R Seed, Whitney R Steele, Katy Davison, …

Vox Sanguinis, Vol.117(4), pp.476-487

2022

DOI: https://doi.org/10.1111/vox.13221

PMID: 34862614

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Abstract

Background and Objectives: Blood donors are increasingly being recognized as an informative resource for surveillance. We aimed to review severe acute respiratory syndrome coronavirus 2 seroprevalence studies conducted among blood donors to investigate methodological biases and provide guidance for future research. Materials and Methods: We conducted a scoping review of peer-reviewed and preprint publications between January 2020 and January 2021. Two reviewers used standardized forms to extract seroprevalence estimates and data on methodology pertaining to population sampling, periodicity, assay characteristics, and antibody kinetics. National data on cumulative incidence and social distancing policies were extracted from publicly available sources and summarized. Results: Thirty-three studies representing 1,323,307 blood donations from 20 countries worldwide were included (sample sizes ranged from 22 to 953,926 donations). The majority of the studies (79%) reported seroprevalence rates <10% (ranging from 0% to 76% [after adjusting for waning antibodies]). Overall, less than 1 in 5 studies reported standardized seroprevalence rates to reflect the demographics of the general population. Stratification by age and sex were most common (64% of studies), followed by region (48%). A total of 52% of studies reported seroprevalence at a single time point. Overall, 27 unique assay combinations were identified, 55% of studies used a single assay and only 39% adjusted seroprevalence rates for imperfect test characteristics. Among the nationally representative studies, case detection was most underrepresented in Kenya (1:1264). Conclusion: By the end of 2020, seroprevalence rates were far from reaching herd immunity. In addition to differences in community transmission and diverse public health policies, study designs and methodology were likely contributing factors to seroprevalence heterogeneity.

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Title: Current challenges of severe acute respiratory syndrome coronavirus 2 seroprevalence studies among blood donors: A scoping review
Authors: Sahar Saeed (Author) - Canadian Blood Services
Samra Uzicanin (Author) - Canadian Blood Services
Antoine Lewin (Author) - Surveillance and Biological Risk Assessment Héma‐Québec Montreal Québec Canada
Ryanne Lieshout‐Krikke (Author) - Sanquin
Helen Faddy (Author) - University of the Sunshine Coast, Queensland, School of Health and Behavioural Sciences - Legacy
Christian Erikstrup (Author) - Aarhus University Hospital
Carla Osiowy (Author) - Public Health Agency of Canada
Clive R Seed (Author) - Australian Red Cross Blood Service
Whitney R Steele (Author) - Epidemiology and Surveillance Group Scientific Affairs, American Red Cross Rockville Maryland USA
Katy Davison (Author) - NHS Blood and Transplant
Brian Custer (Author) - Vitalant
Sheila F O'Brien (Corresponding Author) - Canadian Blood Services
Surveillance Risk Assessment and Policy (SRAP) Sub‐group of the Transfusion Transmitted Infectious Diseases Working Party of the International Society of Blood Transfusion (Research Group)
Publication details: Vox Sanguinis, Vol.117(4), pp.476-487
Publisher: Wiley-Blackwell Publishing Ltd.
Date published: 2022
DOI: 10.1111/vox.13221
ISSN: 1423-0410
PMID: 34862614
Organisation Unit: School of Health - Biomedicine; University of the Sunshine Coast, Queensland; School of Health and Behavioural Sciences - Legacy
Language: English
Record Identifier: 99589108902621
Output Type: Journal article

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Web Of Science research areas: Hematology

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