Journal article
Current challenges of severe acute respiratory syndrome coronavirus 2 seroprevalence studies among blood donors: A scoping review
Vox Sanguinis, Vol.117(4), pp.476-487
2022
Abstract
Background and Objectives:
Blood donors are increasingly being recognized as an informative resource for surveillance. We aimed to review severe acute respiratory syndrome coronavirus 2 seroprevalence studies conducted among blood donors to investigate methodological biases and provide guidance for future research.
Materials and Methods:
We conducted a scoping review of peer-reviewed and preprint publications between January 2020 and January 2021. Two reviewers used standardized forms to extract seroprevalence estimates and data on methodology pertaining to population sampling, periodicity, assay characteristics, and antibody kinetics. National data on cumulative incidence and social distancing policies were extracted from publicly available sources and summarized.
Results:
Thirty-three studies representing 1,323,307 blood donations from 20 countries worldwide were included (sample sizes ranged from 22 to 953,926 donations). The majority of the studies (79%) reported seroprevalence rates <10% (ranging from 0% to 76% [after adjusting for waning antibodies]). Overall, less than 1 in 5 studies reported standardized seroprevalence rates to reflect the demographics of the general population. Stratification by age and sex were most common (64% of studies), followed by region (48%). A total of 52% of studies reported seroprevalence at a single time point. Overall, 27 unique assay combinations were identified, 55% of studies used a single assay and only 39% adjusted seroprevalence rates for imperfect test characteristics. Among the nationally representative studies, case detection was most underrepresented in Kenya (1:1264).
Conclusion:
By the end of 2020, seroprevalence rates were far from reaching herd immunity. In addition to differences in community transmission and diverse public health policies, study designs and methodology were likely contributing factors to seroprevalence heterogeneity.
Details
- Title
- Current challenges of severe acute respiratory syndrome coronavirus 2 seroprevalence studies among blood donors: A scoping review
- Authors
- Sahar Saeed (Author) - Canadian Blood ServicesSamra Uzicanin (Author) - Canadian Blood ServicesAntoine Lewin (Author) - Surveillance and Biological Risk Assessment Héma‐Québec Montreal Québec CanadaRyanne Lieshout‐Krikke (Author) - SanquinHelen Faddy (Author) - University of the Sunshine Coast, Queensland, School of Health and Behavioural Sciences - LegacyChristian Erikstrup (Author) - Aarhus University HospitalCarla Osiowy (Author) - Public Health Agency of CanadaClive R Seed (Author) - Australian Red Cross Blood ServiceWhitney R Steele (Author) - Epidemiology and Surveillance Group Scientific Affairs, American Red Cross Rockville Maryland USAKaty Davison (Author) - NHS Blood and TransplantBrian Custer (Author) - VitalantSheila F O'Brien (Corresponding Author) - Canadian Blood ServicesSurveillance Risk Assessment and Policy (SRAP) Sub‐group of the Transfusion Transmitted Infectious Diseases Working Party of the International Society of Blood Transfusion (Research Group)
- Publication details
- Vox Sanguinis, Vol.117(4), pp.476-487
- Publisher
- Wiley-Blackwell Publishing Ltd.
- DOI
- 10.1111/vox.13221
- ISSN
- 1423-0410
- Organisation Unit
- School of Health and Behavioural Sciences - Legacy; University of the Sunshine Coast, Queensland; School of Health - Biomedicine
- Language
- English
- Record Identifier
- 99589108902621
- Output Type
- Journal article
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- Hematology
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