Curcumin Inhibits Lysophosphatidic Acid Mediated MCP-1 Expression via Blocking ROCK Signalling

Ying Zhou; Peter J Little; Suowen Xu; Danielle Kamato

doi:10.3390/molecules26082320

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Curcumin Inhibits Lysophosphatidic Acid Mediated MCP-1 Expression via Blocking ROCK Signalling

Journal article

Open access

Peer reviewed

Curcumin Inhibits Lysophosphatidic Acid Mediated MCP-1 Expression via Blocking ROCK Signalling

Ying Zhou, Peter J Little, Suowen Xu and Danielle Kamato

Molecules, Vol.26(8), pp.1-12

2021

DOI: https://doi.org/10.3390/molecules26082320

PMCID: PMC8073974

PMID: 33923651

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Abstract

atherosclerosis

monocyte chemoattractant protein-1

Smad2

transforming growth factor receptor

inflammation

vascular smooth muscle cells

Curcumin is a natural compound that has been widely used as a food additive and medicine in Asian countries. Over several decades, diverse biological effects of curcumin have been elucidated, such as anti-inflammatory and anti-oxidative activities. Monocyte chemoattractant protein-1 (MCP-1) is a key inflammatory marker during the development of atherosclerosis, and curcumin blocks MCP-1 expression stimulated by various ligands. Hence, we studied the action of curcumin on lysophosphatidic acid (LPA) mediated MCP-1 expression and explored the specific underlying mechanisms. In human vascular smooth muscle cells, LPA induces Rho-associated protein kinase (ROCK) dependent transforming growth factor receptor (TGFBR1) transactivation, leading to glycosaminoglycan chain elongation. We found that LPA also signals via the TGFBR1 transactivation pathway to regulate MCP-1 expression. Curcumin blocks LPA mediated TGFBR1 transactivation and subsequent MCP-1 expression by blocking the ROCK signalling. In the vasculature, ROCK signalling regulates smooth muscle cell contraction, inflammatory cell recruitment, endothelial dysfunction and vascular remodelling. Therefore, curcumin as a ROCK signalling inhibitor has the potential to prevent atherogenesis via multiple ways.

Details

Title: Curcumin Inhibits Lysophosphatidic Acid Mediated MCP-1 Expression via Blocking ROCK Signalling
Authors: Ying Zhou (Author) - The University of Queensland
Peter J Little (Author) - Sunshine Coast Health Institute (Australian, Birtinya) - SCHI
Suowen Xu (Author) - University of Science and Technology of China
Danielle Kamato (Author) - The University of Queensland
Publication details: Molecules, Vol.26(8), pp.1-12
Publisher: MDPI AG
Date published: 2021
DOI: 10.3390/molecules26082320
ISSN: 1420-3049
PMID: 33923651; PMC8073974
Copyright note: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Organisation Unit: School of Health; University of the Sunshine Coast, Queensland; School of Health and Behavioural Sciences - Legacy
Language: English
Record Identifier: 99533508502621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Biochemistry & Molecular Biology; Chemistry, Multidisciplinary

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