Cumulative solar ultraviolet radiation exposure and basal cell carcinoma of the skin in a nationwide US cohort using satellite and ground-based measures

Mark P Little; Martha S Linet; Michael G Kimlin; Terrence Lee; Zaria Tatalovich; Alice J Sigurdson; Elizabeth K Cahoon

doi:10.1186/s12940-019-0536-9

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Cumulative solar ultraviolet radiation exposure and basal cell carcinoma of the skin in a nationwide US cohort using satellite and ground-based measures

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Cumulative solar ultraviolet radiation exposure and basal cell carcinoma of the skin in a nationwide US cohort using satellite and ground-based measures

Mark P Little, Martha S Linet, Michael G Kimlin, Terrence Lee, Zaria Tatalovich, Alice J Sigurdson and Elizabeth K Cahoon

Environmental Health, Vol.18, 114

2019

DOI: https://doi.org/10.1186/s12940-019-0536-9

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Abstract

non-ionizing radiation

ultraviolet solar radiation

basal cell carcinoma of the skin

radiologic technologist

Background: Basal cell carcinoma of the skin (BCC) is the most common cancer in populations of European ancestry. Although consistently linked with basal cell carcinoma of the skin in case-control studies, few prospective cohort studies have evaluated the shape of the exposure-response of basal cell carcinoma associated with cumulative radiant solar ultraviolet exposure (UVR). Methods: We followed 63,912 white cancer-free US radiologic technologists from entry (1983-1998) to exit (2003-2005) with known ultraviolet irradiance at up to 5 residential locations. Using generalized-additive and relative risk models we analyzed the exposure-response of basal cell carcinomas associated with ambient cumulative ultraviolet radiant exposure using ground-based National Solar Radiation database Average Daily Total Global data and satellite-based National Aeronautics and Space Administration Total Ozone Mapping Spectrometer data. Results: There were 2151 technologists with an incident primary basal cell carcinoma. Risk of basal cell carcinoma rose with increasing cumulative ultraviolet radiation exposure using both measures, such that 1 MJ cm- 2 increased basal cell carcinoma risk by 8.48 (95% CI 5.22, 11.09, p & 0.001) and by 10.15 (95% CI 6.67, 13.10, p & 0.001) per 10,000 persons per year using the Average Daily Total Global and Total Ozone Mapping Spectrometer ultraviolet data, respectively; relative risk was likewise elevated. There was some evidence of upward curvature in the cumulative ultraviolet exposure response using both exposure measures with a greater increase in risk of basal cell carcinoma at higher levels of ultraviolet radiation exposure, but less evidence for curvature in relative risk. There are indications of substantial variation of relative risk with time after exposure and age at exposure, so that risk is highest for the period 10-14 years after ultraviolet radiation exposure and for those exposed under the age of 25. Conclusions We observed increases in risk of basal cell carcinoma and a similar exposure-response for ground-based and satellite ultraviolet radiation measures. Our observations suggest that interventions should concentrate on persons with higher levels of ultraviolet radiation exposure.

Details

Title: Cumulative solar ultraviolet radiation exposure and basal cell carcinoma of the skin in a nationwide US cohort using satellite and ground-based measures
Authors: Mark P Little (Author) - National Cancer Institute, United States
Martha S Linet (Author) - National Cancer Institute, United States
Michael G Kimlin (Author) - University of the Sunshine Coast
Terrence Lee (Author) - National Cancer Institute, United States
Zaria Tatalovich (Author) - National Cancer Institute, United States
Alice J Sigurdson (Author) - National Cancer Institute, United States
Elizabeth K Cahoon (Author) - National Cancer Institute, United States
Publication details: Environmental Health, Vol.18, 114; 10
Publisher: BioMed Central Ltd.
Date published: 2019
DOI: 10.1186/s12940-019-0536-9
ISSN: 1476-069X
Copyright note: Copyright © The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Organisation Unit: University of the Sunshine Coast, Queensland; School of Health and Sport Sciences - Legacy
Language: English
Record Identifier: 99450822502621
Output Type: Journal article

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