CtHtrA: The lynchpin of the chlamydial surface and a promising therapeutic target

James W Marsh; Vanissa A Ong; William B Lott; Peter Timms; Joel D A Tyndall; Wilhelmina M Huston

doi:10.2217/fmb-2017-0017

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CtHtrA: The lynchpin of the chlamydial surface and a promising therapeutic target

Journal article

Peer reviewed

CtHtrA: The lynchpin of the chlamydial surface and a promising therapeutic target

James W Marsh, Vanissa A Ong, William B Lott, Peter Timms, Joel D A Tyndall and Wilhelmina M Huston

Future Microbiology, Vol.12(9), pp.817-829

2017

DOI: https://doi.org/10.2217/fmb-2017-0017

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Abstract

DegP

HtrA

intracellular

protease

virulence

Chlamydia trachomatis is the most prevalent sexually transmitted bacterial infection worldwide and the leading cause of preventable blindness. Reports have emerged of treatment failure, suggesting a need to develop new antibiotics to battle Chlamydia infection. One possible candidate for a new treatment is the protease inhibitor JO146, which is an effective anti-Chlamydia agent that targets the CtHtrA protein. CtHtrA is a lynchpin on the chlamydial cell surface due to its essential and multifunctional roles in the bacteria's stress response, replicative phase of development, virulence and outer-membrane protein assembly. This review summarizes the current understanding of CtHtrA function and presents a mechanistic model that highlights CtHtrA as an effective target for anti-Chlamydia drug development.

Details

Title: CtHtrA: The lynchpin of the chlamydial surface and a promising therapeutic target
Authors: James W Marsh (Author) - University of Technology Sydney
Vanissa A Ong (Author) - Queensland University of Technology
William B Lott (Author) - Queensland University of Technology
Peter Timms (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
Joel D A Tyndall (Author) - University of Otago, New Zealand
Wilhelmina M Huston (Author) - University of Techology Sydney
Publication details: Future Microbiology, Vol.12(9), pp.817-829
Publisher: Future Medicine Ltd.
Date published: 2017
DOI: 10.2217/fmb-2017-0017
ISSN: 1746-0913
Organisation Unit: University of the Sunshine Coast, Queensland; Centre for Bioinnovation
Language: English
Record Identifier: 99449361002621
Output Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Microbiology

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