Journal article
Crusted scabies is associated with increased IL-17 secretion by skin T cells
Parasite Immunology, Vol.36(11), pp.594-604
2014
Abstract
Scabies is an ectoparasitic infestation by the mite Sarcoptes scabiei. Although commonly self-limiting, a fraction of patients develop severely debilitating crusted scabies. The immune mechanisms underlying the development of crusted scabies are unclear, and undertaking longitudinal infection studies in humans is difficult. We utilized a porcine model to compare cellular immune responses in peripheral blood and skin of pigs with different clinical manifestations of scabies (n=12), and in uninfected controls (n=6). Although clinical symptoms were not evident until at least 4 weeks post infestation, the numbers of peripheral IFNγ secreting CD4+ T cells and γδ T cells increased in infected pigs from week 1 post infestation. γδ T cells remained elevated in the blood at week 15 post infestation. At week 15, skin cell infiltrates from pigs with crusted scabies had significantly higher CD8+ T cell, γδ T cell, and IL-17+ cell numbers than those with ordinary scabies. Peripheral IL-17 levels were not increased, suggesting that localised skin IL-17 secreting T cells may play a critical role in the pathogenesis of crusted scabies development. Given the potential of anti-IL-17 immunotherapy demonstrated for other inflammatory skin diseases, this study may provide a novel therapeutic avenue for patients with recurrent crusted scabies.
Details
- Title
- Crusted scabies is associated with increased IL-17 secretion by skin T cells
- Authors
- Xiao Song Liu (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and EngineeringShelley F Walton (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and EngineeringHugh C Murray (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and EngineeringMallory King (Author) - QIMR Berghofer Medical Research Institute, AustraliaAndrew Kelly (Author) - University of QueenslandDeborah C Holt (Author) - Charles Darwin UniversityBart J Currie (Author) - Charles Darwin UniversityJames S McCarthy (Author) - University of QueenslandKate E Mounsey (Author) - University of the Sunshine Coast - Faculty of Science, Health, Education and Engineering
- Publication details
- Parasite Immunology, Vol.36(11), pp.594-604
- Publisher
- Wiley-Blackwell Publishing Ltd.
- Date published
- 2014
- DOI
- 10.1111/pim.12129
- ISSN
- 0141-9838
- Copyright note
- Copyright © 2014 Wiley-Blackwell Publishing Ltd. This is the accepted version of the following article: Liu, X., Walton, S. F., Murray, H. C., King, M., Kelly, A., Holt, D. C., Currie, B. J., McCarthy, J. S. and Mounsey, K. E. (2014), Crusted scabies is associated with increased IL-17 secretion by skin T cells. Parasite Immunology, 36: 594-604. doi: 10.1111/pim.12129, which has been published in final form at http://dx.doi.org/10.1111/pim.12129
- Organisation Unit
- School of Health - Biomedicine; University of the Sunshine Coast, Queensland; GeneCology Research Centre - Legacy; School of Health and Sport Sciences - Legacy; School of Health and Behavioural Sciences - Legacy
- Language
- English
- Record Identifier
- 99448874602621
- Output Type
- Journal article
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- Immunology
- Parasitology
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