Craving Mediates Stress in Predicting Lapse During Alcohol Dependence Treatment

Bonnie Law; Matthew J Gullo; Mark Daglish; David J Kavanagh; Gerald F X Feeney; Ross Young; Jason P Connor

doi:10.1111/acer.13034

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Craving Mediates Stress in Predicting Lapse During Alcohol Dependence Treatment

Journal article

Peer reviewed

Craving Mediates Stress in Predicting Lapse During Alcohol Dependence Treatment

Bonnie Law, Matthew J Gullo, Mark Daglish, David J Kavanagh, Gerald F X Feeney, Ross Young and Jason P Connor

Alcoholism: Clinical and Experimental Research, Vol.40(5), pp.1058-1064

2016

DOI: https://doi.org/10.1111/acer.13034

PMID: 27012658

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Abstract

Background: Stress, craving, and depressed mood have all been implicated in alcohol use treatment lapses. Few studies have examined all 3 factors. Progress has been limited because of difficulties with craving assessment. The Alcohol Craving Experience Questionnaire (ACE) is a new measure of alcohol craving. It is both psychometrically sound and conceptually rigorous. This prospective study examines a stress–treatment response model that incorporates mediation by craving and moderation by depressed mood and pharmacotherapy. Methods: Five hundred and thirty-nine consecutively treated alcohol-dependent patients voluntarily participated in an abstinence-based 12-week cognitive-behavioral therapy (CBT) program at a hospital alcohol and drug outpatient clinic. Measures of stress, craving, depressed mood, and alcohol dependence severity were administered prior to treatment. Treatment lapse and treatment dropout were assessed over the 12-week program duration. Results: Patients reporting greater stress experienced stronger and more frequent cravings. Stronger alcohol craving predicted lapse, after controlling for dependence severity, stress, depression, and pharmacotherapy. Alcohol craving mediated stress to predict lapse. Depressed mood and anticraving medication were not significant moderators. Conclusions: Among treatment seeking, alcohol-dependent patients, craving mediated the relationship between stress and lapse. The effect was not moderated by depressed mood or anticraving medication.

Details

Title: Craving Mediates Stress in Predicting Lapse During Alcohol Dependence Treatment
Authors: Bonnie Law (Author) - University of Queensland
Matthew J Gullo (Author) - University of Queensland
Mark Daglish (Author) - University of Queensland
David J Kavanagh (Author) - Queensland University of Technology
Gerald F X Feeney (Author) - University of Queensland
Ross Young (Author) - Queensland University of Technology
Jason P Connor (Author) - University of Queensland
Publication details: Alcoholism: Clinical and Experimental Research, Vol.40(5), pp.1058-1064
Publisher: Wiley-Blackwell Publishing, Inc.
DOI: 10.1111/acer.13034
ISSN: 1530-0277
PMID: 27012658
Organisation Unit: Office of the Deputy Vice-Chancellor (Research and Innovation); University of the Sunshine Coast, Queensland
Language: English
Record Identifier: 99551002002621
Output Type: Journal article

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Collaboration types: Domestic collaboration
Web Of Science research areas: Substance Abuse

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