Corticotrophin-releasing hormone and corticotrophin-releasing hormone binding protein in normal and pre-eclamptic human pregnancies

A. V Perkins; E. A Linton; F Eben; J Simpson; C. D. A Wolfe; C. W. G Redman

doi:10.1111/j.1471-0528.1995.tb09063.x

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Corticotrophin-releasing hormone and corticotrophin-releasing hormone binding protein in normal and pre-eclamptic human pregnancies

Journal article

Peer reviewed

Corticotrophin-releasing hormone and corticotrophin-releasing hormone binding protein in normal and pre-eclamptic human pregnancies

A. V Perkins, E. A Linton, F Eben, J Simpson, C. D. A Wolfe and C. W. G Redman

British Journal of Obstetrics and Gynaecology, Vol.102(2), pp.118-122

1995

DOI: https://doi.org/10.1111/j.1471-0528.1995.tb09063.x

PMID: 7756202

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Abstract

Objective: To measure the plasma levels of corticotrophin-releasing hormone and corticotrophin-releasing hormone binding protein in normal pregnancy and in pregnancies complicated by pre-eclampsia. Setting: John Radcliffe Hospital, Oxford and St Thomas's Hospital, London. Subjects: One hundred and twenty pregnant women sampled prospectively throughout gestation, of whom 91 experienced a normal pregnancy and eight developed pre-eclampsia; in a second study, 10 women with severe pre-eclampsia, presenting at a range of gestational ages, were sampled once and compared with appropriately matched normal pregnant women. Main outcome measure: Plasma levels of corticotrophin-releasing hormone determined by immunoradiometric assay. Plasma levels of corticotrophin-releasing hormone binding protein measured by direct radioimmunoassay. Results: In the prospective study, plasma samples from women with pre-eclampsia exhibited higher (390.2 versus 292.7 pmol/l at 36 weeks) levels of corticotrophin-releasing hormone and significantly lower (5.24 versus 8.14 nmol/l at 36 weeks, P 0.002) levels of corticotrophin-releasing hormone binding protein than normal controls. In the second, single time point study a significant elevation in CRH (P < 0.002) and reduction in CRH-BP (P < 0.001) was found in pre-eclamptic pregnancies compared with controls. Conclusions: In human pregnancies complicated by pre-eclampsia there is an elevated level of corticotrophin releasing hormone whilst there is less corticotrophin-releasing hormone binding protein; therefore there is a net increase in free potentially bioactive hormone which may play a role in the pathology of the disease.

Details

Title: Corticotrophin-releasing hormone and corticotrophin-releasing hormone binding protein in normal and pre-eclamptic human pregnancies
Authors: A. V Perkins (Author) - John Radcliffe Hospital
E. A Linton (Author) - John Radcliffe Hospital
F Eben (Author) - John Radcliffe Hospital
J Simpson (Author) - John Radcliffe Hospital
C. D. A Wolfe (Author) - John Radcliffe Hospital
C. W. G Redman (Author) - John Radcliffe Hospital
Publication details: British Journal of Obstetrics and Gynaecology, Vol.102(2), pp.118-122
Publisher: Wiley-Blackwell Publishing Ltd.
DOI: 10.1111/j.1471-0528.1995.tb09063.x
ISSN: 1365-215X
PMID: 7756202
Organisation Unit: University of the Sunshine Coast, Queensland; School of Health and Behavioural Sciences - Legacy; School of Health
Language: English
Record Identifier: 99685197702621
Output Type: Journal article

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Collaboration types: Domestic collaboration
Web Of Science research areas: Obstetrics & Gynecology

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