Corticospinal modulation induced by sounds depends on action preparedness

Welber Marinovic; James R Tresilian; Aymar de Rugy; Simranjit Sidhu; Stephan Riek

doi:10.1113/jphysiol.2013.254581

Back

Corticospinal modulation induced by sounds depends on action preparedness

Journal article

Open access

Peer reviewed

Corticospinal modulation induced by sounds depends on action preparedness

Welber Marinovic, James R Tresilian, Aymar de Rugy, Simranjit Sidhu and Stephan Riek

The Journal of physiology, Vol.592(1), pp.153-169

2014

DOI: https://doi.org/10.1113/jphysiol.2013.254581

PMCID: PMC3903357

PMID: 24081157

Files and links (2)

pdf

Corticospinal modulation induced by sounds depends on action preparedness774.77 kBDownload View

Published Version Open Access CC BY V4.0

url

https://doi.org/10.1113/jphysiol.2013.254581View

Published Version Open

Abstract

Motor Cortex - physiology

Movement

Acoustic Stimulation

Humans

Male

Sound

Transcranial Magnetic Stimulation

Evoked Potentials, Motor

Anticipation, Psychological

Deep Brain Stimulation

Adult

Female

Pyramidal Tracts - physiology

A loud acoustic stimulus (LAS) presented during movement preparation can induce an early release of the prepared action. Because loud sound has been found to have an inhibitory effect on motor cortex excitability, it is possible that the motor cortex plays little role in the early release of prepared responses. We sought to shed new light on this suggestion by probing changes in corticospinal excitability after LAS presentation during preparation for an anticipatory action. Unexpectedly, we show that the changes in corticospinal excitability after LAS presentation are not fixed. Based on the magnitude of motor-evoked potentials elicited by transcranial magnetic and electric stimulation of the motor cortex, we demonstrate that the effects of auditory stimuli on corticospinal excitability depend on the level of readiness for action: inhibition in early preparation and facilitation close to movement onset. We also show that auditory stimuli can regulate intracortical excitability by increasing intracortical facilitation and reducing short-interval intracortical inhibition. Together, these findings indicate that, at least in part, the early release of motor responses by auditory stimuli involves the motor cortex.

Details

Title: Corticospinal modulation induced by sounds depends on action preparedness
Authors: Welber Marinovic (Author) - The University of Queensland
James R Tresilian (Author) - University of Warwick
Aymar de Rugy (Author) - The University of Queensland
Simranjit Sidhu (Author) - University of Utah
Stephan Riek (Author) - The University of Queensland
Publication details: The Journal of physiology, Vol.592(1), pp.153-169
Publisher: Wiley-Blackwell Publishing Ltd.
Date published: 2014
DOI: 10.1113/jphysiol.2013.254581
ISSN: 1469-7793
PMID: 24081157; PMC3903357
Grant note: W.M. thanks the Australian Research Council for their support in the form of a Discovery Early Career Research Award.
Organisation Unit: Graduate Research School
Language: English
Record Identifier: 99472605702621
Output Type: Journal article

Metrics

11 File views/ downloads

23 Record Views

48 Times Cited - Web of Science

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Neurosciences; Physiology