Cortical abnormalities in adults and adolescents with major depression based on brain scans from 20 cohorts worldwide in the ENIGMA Major Depressive Disorder Working Group

L Schmaal; D P Hibar; P G Sämann; G B Hall; B T Baune; N Jahanshad; J W Cheung; T G M van Erp; D Bos; M A Ikram; M W Vernooij; W J Niessen; H Tiemeier; A Hofman; K Wittfeld; H J Grabe; D Janowitz; R Bülow; M Selonke; H Völzke; D Grotegerd; U Dannlowski; V Arolt; N Opel; W Heindel; H Kugel; D Hoehn; M Czisch; B Couvy-Duchesne; M E Rentería; L T Strike; M J Wright; N T Mills; G I de Zubicaray; K L McMahon; S E Medland; N G Martin; N A Gillespie; R Goya-Maldonado; O Gruber; B Krämer; S N Hatton; Jim Lagopoulos; I B Hickie; T Frodl; A Carballedo; E M Frey; L S van Velzen; B W J H Penninx; M J van Tol; N J van der Wee; C G Davey; B J Harrison; B Mwangi; B Cao; J C Soares; I M Veer; H Walter; D Schoepf; B Zurowski; C Konrad; E Schramm; C Normann; K Schnell; M D Sacchet; I H Gotlib; G M MacQueen; B R Godlewska; T Nickson; A M McIntosh; M Papmeyer; H C Whalley; J Hall; J E Sussmann; M Li; M Walter; L Aftanas; I Brack; N A Bokhan; P M Thompson; D J Veltman

doi:10.1038/mp.2016.60

Back

Cortical abnormalities in adults and adolescents with major depression based on brain scans from 20 cohorts worldwide in the ENIGMA Major Depressive Disorder Working Group

Journal article

Open access

Peer reviewed

Cortical abnormalities in adults and adolescents with major depression based on brain scans from 20 cohorts worldwide in the ENIGMA Major Depressive Disorder Working Group

L Schmaal, D P Hibar, P G Sämann, G B Hall, B T Baune, N Jahanshad, J W Cheung, T G M van Erp, D Bos, M A Ikram, …

Molecular Psychiatry, Vol.22, pp.900-909

2017

DOI: https://doi.org/10.1038/mp.2016.60

Files and links (2)

pdf

PDF - Published Version (Open Access)731.29 kBDownload View

Published Version PDF - Published Version (Open Access) Open Access CC BY V4.0

url

https://doi.org/10.1038/mp.2016.60View

Published Version

Abstract

The neuro-anatomical substrates of major depressive disorder (MDD) are still not well understood, despite many neuroimaging studies over the past few decades. Here we present the largest ever worldwide study by the ENIGMA (Enhancing Neuro Imaging Genetics through Meta-Analysis) Major Depressive Disorder Working Group on cortical structural alterations in MDD. Structural T1-weighted brain magnetic resonance imaging (MRI) scans from 2148 MDD patients and 7957 healthy controls were analysed with harmonized protocols at 20 sites around the world. To detect consistent effects of MDD and its modulators on cortical thickness and surface area estimates derived from MRI, statistical effects from sites were meta-analysed separately for adults and adolescents. Adults with MDD had thinner cortical gray matter than controls in the orbitofrontal cortex (OFC), anterior and posterior cingulate, insula and temporal lobes (Cohen's d effect sizes: -0.10 to -0.14). These effects were most pronounced in first episode and adult-onset patients (>21 years). Compared to matched controls, adolescents with MDD had lower total surface area (but no differences in cortical thickness) and regional reductions in frontal regions (medial OFC and superior frontal gyrus) and primary and higher-order visual, somatosensory and motor areas (d: -0.26 to -0.57). The strongest effects were found in recurrent adolescent patients. This highly powered global effort to identify consistent brain abnormalities showed widespread cortical alterations in MDD patients as compared to controls and suggests that MDD may impact brain structure in a highly dynamic way, with different patterns of alterations at different stages of life.Molecular Psychiatry advance online publication, 3 May 2016; doi:10.1038/mp.2016.60. © 2016 Macmillan Publishers Limited

Details

Title: Cortical abnormalities in adults and adolescents with major depression based on brain scans from 20 cohorts worldwide in the ENIGMA Major Depressive Disorder Working Group
Authors: L Schmaal (Author)
D P Hibar (Author)
P G Sämann (Author)
G B Hall (Author)
B T Baune (Author)
N Jahanshad (Author)
J W Cheung (Author)
T G M van Erp (Author)
D Bos (Author)
M A Ikram (Author)
M W Vernooij (Author)
W J Niessen (Author)
H Tiemeier (Author)
A Hofman (Author)
K Wittfeld (Author)
H J Grabe (Author)
D Janowitz (Author)
R Bülow (Author)
M Selonke (Author)
H Völzke (Author)
D Grotegerd (Author)
U Dannlowski (Author)
V Arolt (Author)
N Opel (Author)
W Heindel (Author)
H Kugel (Author)
D Hoehn (Author)
M Czisch (Author)
B Couvy-Duchesne (Author)
M E Rentería (Author)
L T Strike (Author)
M J Wright (Author)
N T Mills (Author)
G I de Zubicaray (Author)
K L McMahon (Author)
S E Medland (Author)
N G Martin (Author)
N A Gillespie (Author)
R Goya-Maldonado (Author)
O Gruber (Author)
B Krämer (Author)
S N Hatton (Author)
Jim Lagopoulos (Author) - University of the Sunshine Coast
I B Hickie (Author)
T Frodl (Author)
A Carballedo (Author)
E M Frey (Author)
L S van Velzen (Author)
B W J H Penninx (Author)
M J van Tol (Author)
N J van der Wee (Author)
C G Davey (Author)
B J Harrison (Author)
B Mwangi (Author)
B Cao (Author)
J C Soares (Author)
I M Veer (Author)
H Walter (Author)
D Schoepf (Author)
B Zurowski (Author)
C Konrad (Author)
E Schramm (Author)
C Normann (Author)
K Schnell (Author)
M D Sacchet (Author)
I H Gotlib (Author)
G M MacQueen (Author)
B R Godlewska (Author)
T Nickson (Author)
A M McIntosh (Author)
M Papmeyer (Author)
H C Whalley (Author)
J Hall (Author)
J E Sussmann (Author)
M Li (Author)
M Walter (Author)
L Aftanas (Author)
I Brack (Author)
N A Bokhan (Author)
P M Thompson (Author)
D J Veltman (Author)
Publication details: Molecular Psychiatry, Vol.22, pp.900-909
Publisher: Nature Publishing Group
Date published: 2017
DOI: 10.1038/mp.2016.60
ISSN: 1359-4184
Copyright note: Copyright © 2016 The Author. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Organisation Unit: University of the Sunshine Coast, Queensland; Thompson Institute
Language: English
Record Identifier: 99451012702621
Output Type: Journal article

Metrics

104 File views/ downloads

8015 Record Views

935 Times Cited - Web of Science

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Highly Cited Paper

Collaboration types: Domestic collaboration; International collaboration
Web Of Science research areas: Biochemistry & Molecular Biology; Neurosciences; Psychiatry

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

Source: InCites