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Accepted VersionCC BY-NC-ND V4.0, Open Access
Journal article
Correlation between interferon γ and interleukin 6 with PTSD and resilience
Psychiatry Research, Vol.260, pp.193-198
2018
PMID: 29202383
Abstract
Posttraumatic Stress Disorder (PTSD) is a debilitating psychiatric disorder with decreased general health prognosis and increased mortality. Inflammation has been hypothesised to be a link between PTSD and the most common co-morbid medical disorders. However, the relationship between inflammation and PTSD is not clear. Individual inflammatory markers have shown variable associations with PTSD. This study investigates the correlations between serum cytokines, PTSD and resilience in a cohort of Caucasian Vietnam combat veterans (n = 299). After correction for multiple testing, PTSD severity was correlated with small but significant decreases in interleukin 6 and interferon γ (p = 0.004, p = 0.013, respectively) whereas resilience was correlated with increased levels of interleukin 6 and interferon γ (p = 0.023; p = 0.007, respectively). Analyses of sub-symptoms of PTSD revealed that mood and arousal symptoms showed the most significant effect on interleukin 6 and interferon γ. More research is needed to further elucidate the mechanisms underlying the relationship between cytokine levels, PTSD sub-symptoms and trauma outcomes to improve the knowledge base of differences in trauma response and the biological system.
Details
- Title
- Correlation between interferon γ and interleukin 6 with PTSD and resilience
- Authors
- Dagmar Bruenig (Author) - Queensland University of TechnologyDivya Mehta (Author) - Queensland University of TechnologyCharles P Morris (Author) - Queensland University of TechnologyBruce Lawford (Author) - Queensland University of TechnologyWendy Harvey (Author) - Greenslopes Private HospitalRoss Young (Author) - Queensland University of TechnologyJoanne Voisey (Author) - Queensland University of Technology
- Publication details
- Psychiatry Research, Vol.260, pp.193-198
- Publisher
- Elsevier Ireland Ltd.
- Date published
- 2018
- DOI
- 10.1016/j.psychres.2017.11.069
- ISSN
- 1872-7123; 0165-1781
- PMID
- 29202383
- Copyright note
- Copyright © 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
- Organisation Unit
- University of the Sunshine Coast, Queensland; Office of the Deputy Vice-Chancellor (Research and Innovation)
- Language
- English
- Record Identifier
- 99551002502621
- Output Type
- Journal article
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