Journal article
Correlating anterior insula gray matter volume changes in young people with clinical and neurocognitive outcomes: an MRI study
BMC Psychiatry, Vol.12, 45
2012
Abstract
Background: The anterior insula cortex is considered to be both the structural and functional link between experience, affect, and behaviour. Magnetic resonance imaging (MRI) studies have shown changes in anterior insula gray matter volume (GMV) in psychosis, bipolar, depression and anxiety disorders in older patients, but few studies have investigated insula GMV changes in young people. This study examined the relationship between anterior insula GMV, clinical symptom severity and neuropsychological performance in a heterogeneous cohort of young people presenting for mental health care.Methods: Participants with a primary diagnosis of depression (n = 43), bipolar disorder (n = 38), psychosis (n = 32), anxiety disorder (n = 12) or healthy controls (n = 39) underwent structural MRI scanning, and volumetric segmentation of the bilateral anterior insula cortex was performed using the FreeSurfer application. Statistical analysis examined the linear and quadratic correlations between anterior insula GMV and participants' performance in a battery of clinical and neuropsychological assessments.Results: Compared to healthy participants, patients had significantly reduced GMV in the left anterior insula (t = 2.05, p = .042) which correlated with reduced performance on a neuropsychological task of attentional set-shifting (Ï = .32, p = .016). Changes in right anterior insula GMV was correlated with increased symptom severity (r = .29, p = .006) and more positive symptoms (r = .32, p = .002).Conclusions: By using the novel approach of examining a heterogeneous cohort of young depression, anxiety, bipolar and psychosis patients together, this study has demonstrated that insula GMV changes are associated with neurocognitive deficits and clinical symptoms in such young patients. © 2012 Hatton et al.; licensee BioMed Central Ltd.
Details
- Title
- Correlating anterior insula gray matter volume changes in young people with clinical and neurocognitive outcomes: an MRI study
- Authors
- S N Hatton (Author) - University of SydneyJim Lagopoulos (Author) - University of SydneyDaniel F Hermens (Author) - University of SydneyS L Naismith (Author) - University of SydneyMaxwell Bennett (Author) - University of SydneyI B Hickie (Author) - University of Sydney
- Publication details
- BMC Psychiatry, Vol.12, 45
- Publisher
- BioMed Central Ltd.
- Date published
- 2012
- DOI
- 10.1186/1471-244X-12-45
- ISSN
- 1471-244X
- Copyright note
- Copyright © 2012 Hatton et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- Organisation Unit
- University of the Sunshine Coast, Queensland; Thompson Institute
- Language
- English
- Record Identifier
- 99448911902621
- Output Type
- Journal article
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- Psychiatry
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